School of Biological Sciences, University of Reading, Whiteknights, Reading, RG6 6EX, UK.
Present address: Department of Internal and Preventive Medicine, College of Veterinary Medicine, University of Al-qadisiyah, Aldewanyiah, Iraq.
Microbiology (Reading). 2023 Mar;169(3). doi: 10.1099/mic.0.001314.
is a common colonizer of the human gut and in doing so it must be able to resist the actions of the host's innate defences. Bile salts are a class of molecules that possess potent antibacterial activity that control growth. Bacteria that colonize and survive in that niche must be able to resist the action of bile salts, but the mechanisms by which does so are poorly understood. Here we show that FadB is a bile-induced oxidoreductase which mediates bile salt resistance and when heterologously expressed in renders them resistant. Deletion of attenuated survival of in a model of the human distal colon.
是人类肠道的常见定植菌，因此它必须能够抵抗宿主先天防御的作用。胆盐是一类具有强大抗菌活性的分子，可控制生长。在该生态位中定植和存活的细菌必须能够抵抗胆盐的作用，但对其机制知之甚少。在这里，我们表明 FadB 是一种胆汁诱导的氧化还原酶，可介导胆盐耐药性，并且当在 中异源表达时，可使它们具有耐药性。在人类远端结肠模型中，缺失 会削弱 的存活能力。
