Jiang Junjie, Li Dong, Huang Tao, Huang Shan, Tan Hanyu, Xia Zhongfang
Department of Otolaryngology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Nutr. 2024 Oct 2;11:1453064. doi: 10.3389/fnut.2024.1453064. eCollection 2024.
Sleep disorders have emerged as a major public health concern. Observational research indicates that antioxidants might mitigate the risk of sleep disturbances, yet the causal relationship remains uncertain.
This study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning 2011 to 2018, focusing on adults who reported sleep disorders. The analysis included 25,178 American adults. We examined the association between the Composite Dietary Antioxidant Index (CDAI) and the prevalence of sleep disorders. Additionally, a two-sample Mendelian randomization analysis was conducted to explore the potential causal link between CDAI and the risk of sleep disorders.
Analysis of data from the 2011-2018 NHANES survey revealed a significant negative association between CDAI and sleep disorders (OR = 0.854, 95% CI 0.821-0.888, < 0.001). A multivariable logistic regression model showed that each unit increase in CDAI corresponded to a 14.6% reduction in sleep disorder risk, exhibiting a nonlinear trend where the risk decreased until reaching the inflection point of -0.134. Additionally, MR analysis demonstrated that genetically determined selenium reduces the risk of OSA (OR = 0.992, 95% CI 0.860-0.989, = 0.023). Furthermore, vitamin E (γ-tocopherol) and vitamin C were protective against sleep-wake disorders (OR = 0.016, 95% CI 0.001-0.674, = 0.03) and (OR = 0.049, 95% CI 0.007-0.346, = 0.002), respectively.
Dietary antioxidants may help prevent sleep disorders. However, further studies are required to clarify the pathways through which antioxidants exert this protective effect.
睡眠障碍已成为一个主要的公共卫生问题。观察性研究表明，抗氧化剂可能会降低睡眠障碍的风险，但因果关系仍不确定。
本研究利用了2011年至2018年美国国家健康与营养检查调查（NHANES）的数据，重点关注报告有睡眠障碍的成年人。分析纳入了25178名美国成年人。我们研究了综合膳食抗氧化指数（CDAI）与睡眠障碍患病率之间的关联。此外，还进行了两样本孟德尔随机化分析，以探讨CDAI与睡眠障碍风险之间的潜在因果关系。
对2011 - 2018年NHANES调查数据的分析显示，CDAI与睡眠障碍之间存在显著的负相关（OR = 0.854，95% CI 0.821 - 0.888，< 0.001）。多变量逻辑回归模型显示，CDAI每增加一个单位，睡眠障碍风险相应降低14.6%，呈现出非线性趋势，即风险降低直至达到-0.134的拐点。此外，孟德尔随机化分析表明，基因决定的硒可降低阻塞性睡眠呼吸暂停（OSA）的风险（OR = 0.992，95% CI 0.860 - 0.989， = 0.023）。此外，维生素E（γ-生育酚）和维生素C分别对睡眠-觉醒障碍具有保护作用（OR = 0.016，95% CI 0.001 - 0.674， = 0.03）和（OR = 0.049，95% CI 0.007 - 0.346, = 0.002）。
膳食抗氧化剂可能有助于预防睡眠障碍。然而，需要进一步研究以阐明抗氧化剂发挥这种保护作用的途径。
