Alharbi Khalid Saad
Department of Pharmacology and Toxicology, Unaizah College of Pharmacy, Qassim University, Qassim 51452, Saudi Arabia.
Pathol Res Pract. 2024 Mar;255:155170. doi: 10.1016/j.prp.2024.155170. Epub 2024 Jan 28.
Hepatitis is a worldwide health issue that causes inflammation of the liver and is frequently brought on by viral infections, specifically those caused by the hepatitis B and C viruses. Although the pathophysiological causes of hepatitis are complex, recent research indicates that noncoding RNAs (ncRNAs) play a crucial role in regulating apoptosis, an essential process for maintaining liver homeostasis and advancing the illness. Noncoding RNAs have been linked to several biological processes, including apoptosis. These RNAs include microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). Distinct expression patterns characterising different stages of the disease have been discovered, indicating dysregulation of these non-coding RNAs in liver tissues infected with hepatitis. The complex interplay that exists between these noncoding RNAs and apoptotic effectors, including caspases and members of the Bcl-2 family, plays a role in the precarious equilibrium that regulates cell survival and death during hepatitis. The purpose of this review is to provide an overview of ncRNA-mediated apoptosis in hepatitis, as well as insights into possible therapeutic targets and diagnostic indicators.
肝炎是一个全球性的健康问题，它会导致肝脏炎症，通常由病毒感染引起，特别是由乙型和丙型肝炎病毒引起的感染。尽管肝炎的病理生理原因很复杂，但最近的研究表明，非编码RNA（ncRNA）在调节细胞凋亡中起着关键作用，细胞凋亡是维持肝脏内环境稳定和疾病进展的一个重要过程。非编码RNA与包括细胞凋亡在内的多种生物学过程有关。这些RNA包括微小RNA（miRNA）、长链非编码RNA（lncRNA）和环状RNA（circRNA）。已经发现了表征疾病不同阶段的不同表达模式，这表明在感染肝炎的肝组织中这些非编码RNA存在失调。这些非编码RNA与凋亡效应器（包括半胱天冬酶和Bcl-2家族成员）之间存在的复杂相互作用，在肝炎期间调节细胞存活和死亡的不稳定平衡中发挥作用。本综述的目的是概述ncRNA介导的肝炎细胞凋亡，以及对可能的治疗靶点和诊断指标的见解。
