Prefrontal cortex and the sequencing of movement in monkeys (Macaca mulatta).

There have been suggestions that the prefrontal cortex may play a role in the regulation of higher-order sequences of behaviour. In this experiment monkeys were taught a sequence of three movements. After removal of either sulcus principalis or the superior prefrontal convexity monkeys were able to perform the sequence normally. After removal of arcuate cortex (areas 8 and 6) monkeys were slow to learn the task; but it is argued that their impairment may not be one of sequencing per se.