Lee Jeeyoo, Shin Aesun, Shin Woo-Kyoung, Choi Ji-Yeob, Kang Daehee
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
Cancer Research Institute, Seoul National University, Seoul , Korea.
Epidemiol Health. 2025 May 9:e2025026. doi: 10.4178/epih.e2025026.
The Korean National Code Against Cancer was released in 2006. These guidelines aimed to promote a healthy lifestyle to prevent cancer risk through 10 recommendations. The objective of this study was to investigate the associations between adherence to the Korean National Code Against Cancer and the risk of all-cause, cancer, and cardiovascular disease (CVD) mortality among Koreans.
This prospective cohort study included 109,160 Korean adults aged 40 to 69 years, recruited from 2004 to 2013 in the population-based Health Examinees-Gem Study (HEXA-G). The adherence total score was calculated based on 6 items from the Korean National Code Against Cancer: smoking, consuming vegetables and fruits, limiting salty foods, restricting alcohol intake, engaging in physical activity, and maintaining a healthy weight. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of adherence scores with mortality risk were estimated using a Cox proportional hazards regression model.
During a mean follow-up period of 12.0 years, 3,799 deaths were recorded. According to the multivariable-adjusted model, men in the highest tertile of adherence scores had a lower risk of all-cause, cancer, and CVD mortality compared to those in the lowest tertile (all-cause: HR=0.67, 95% CI=0.60-0.74; cancer: HR=0.63, 95% CI=0.54-0.74; CVD: HR=0.56, 95% CI=0.43-0.73). A similar association was observed among women for all-cause and CVD mortality (all-cause: HR=0.85, 95% CI=0.76-0.96; CVD: HR=0.70, 95% CI=0.51-0.97).
Adherence to the Korean National Code Against Cancer was associated with a reduced risk of all-cause, cancer, and CVD mortality.
《韩国抗癌国家准则》于2006年发布。这些指南旨在通过10项建议来促进健康的生活方式以预防癌症风险。本研究的目的是调查韩国人对《韩国抗癌国家准则》的遵循情况与全因死亡率、癌症死亡率和心血管疾病（CVD）死亡率之间的关联。
这项前瞻性队列研究纳入了2004年至2013年从基于人群的健康体检者-宝石研究（HEXA-G）中招募的109,160名40至69岁的韩国成年人。遵循总分是根据《韩国抗癌国家准则》的6项内容计算得出的：吸烟、食用蔬菜和水果、限制高盐食物、限制酒精摄入、进行体育活动以及保持健康体重。使用Cox比例风险回归模型估计遵循得分与死亡风险之间关联的风险比（HRs）和95%置信区间（CIs）。
在平均12.0年的随访期内，记录了3799例死亡病例。根据多变量调整模型，遵循得分处于最高三分位数的男性与最低三分位数的男性相比，全因死亡率、癌症死亡率和CVD死亡率风险更低（全因死亡率：HR = 0.67，95% CI = 0.60 - 0.74；癌症死亡率：HR = 0.63，95% CI = 0.54 - 0.74；CVD死亡率：HR = 0.56，95% CI = 0.43 - 0.73）。在女性中，全因死亡率和CVD死亡率也观察到了类似的关联（全因死亡率：HR = 0.85，95% CI = 0.76 - 0.96；CVD死亡率：HR = 0.70，95% CI = 0.51 - 0.97）。
遵循《韩国抗癌国家准则》与降低全因死亡率、癌症死亡率和CVD死亡率风险相关。
