Ovington K S
Parasitology. 1985 Aug;91 ( Pt 1):157-67. doi: 10.1017/s0031182000056596.
The pattern of daily food intake of well-nourished rats infected with Nippostrongylus brasiliensis included 2 distinct phases when food intake was much less than that of uninfected controls (days 0-4 and days 6-10 p.i.). These phases were separated by a period (days 4-6) of still reduced but relatively constant food intake. From day 10 p.i. food intake increased so that between days 12 and 17 infected rats ate more than uninfected controls. In each of the phases of reduced food intake there was a threshold dose above which food intake was further decreased as dose increased. In contrast to the obvious relationship between food intake and dose, food intake could not easily be related to the size of the adult Nippostrongylus population, as judged by egg and worm counts. The relationship appears to be complicated by host variability in susceptibility to infection and to the pathological effects of infection. Effects of N. brasiliensis on the daily pattern of food intake can be explained with respect to stages in the development of the parasite and host responses directed against the adult worms.
感染巴西日圆线虫的营养良好的大鼠的每日食物摄入量模式包括两个不同阶段，即食物摄入量远低于未感染对照组的阶段（感染后0 - 4天和6 - 10天）。这两个阶段被一个食物摄入量仍减少但相对稳定的时期（4 - 6天）隔开。从感染后第10天起，食物摄入量增加，以至于在12至17天期间，感染大鼠的食量超过未感染对照组。在食物摄入量减少的每个阶段，都存在一个阈值剂量，超过该剂量后，食物摄入量会随着剂量增加而进一步减少。与食物摄入量和剂量之间明显的关系形成对比的是，根据虫卵和虫体计数判断，食物摄入量与成年巴西日圆线虫种群数量之间的关系并不明显。这种关系似乎因宿主对感染的易感性以及感染的病理效应的变异性而变得复杂。巴西日圆线虫对每日食物摄入模式的影响可以根据寄生虫发育阶段和针对成虫的宿主反应来解释。
