Keymer A, Crompton D W, Walters D E
Parasitology. 1983 Jun;86 (Pt 3):461-75. doi: 10.1017/s0031182000050654.
The synergistic relationship between host nutrition and the effects of Nippostrongylus was investigated experimentally in rats fed a diet containing 1% (w/w) protein. Rats were infected with 10 doses of N. brasiliensis varying from 0.35 to 99 larvae/g and their daily food intake and weekly body mass were compared with those uninfected rats fed the same diet for a period of 9 weeks. The deterioration of the uninfected rats observed as a result of protein-energy malnutrition was found to be accelerated in a dose-dependent manner in the rats infected with N. brasiliensis. Analysis of food intake and body mass measurements demonstrated that this acceleration was related to a decrease in food intake and indicated a likely alteration in nutrient utilization, both of which were established by the end of the first week of the infection. Remission from the combined effects of malnutrition and infection was achieved by offering the rats a high-protein diet (20% w/w), whereupon rehabilitation was found to be complete within a period of 9 days. The implications of the results and the possible mechanisms involved in their generation are discussed in relation to the frequent coexistence of helminthiasis and malnutrition.
在以含1%（重量/重量）蛋白质的饲料喂养的大鼠中，通过实验研究了宿主营养与巴西日圆线虫感染效应之间的协同关系。将大鼠感染10个剂量的巴西日圆线虫，剂量范围为每克0.35至99条幼虫，并将它们的每日食物摄入量和每周体重与喂食相同饲料的未感染大鼠在9周内的情况进行比较。结果发现，因蛋白质 - 能量营养不良而观察到的未感染大鼠的身体恶化，在感染巴西日圆线虫的大鼠中以剂量依赖的方式加速。对食物摄入量和体重测量的分析表明，这种加速与食物摄入量的减少有关，并且表明营养物质利用可能发生改变，这两者在感染的第一周结束时就已确定。通过给大鼠提供高蛋白饮食（20%重量/重量），实现了营养不良和感染联合效应的缓解，随后发现在9天内完全康复。结合蠕虫病和营养不良经常并存的情况，讨论了这些结果的意义及其产生的可能机制。
