Pérez-Ramos Paula, Godinho Patrícia I C, Soengas Raquel G, Rodríguez-Solla Humberto
Department of Organic and Inorganic Chemistry, Instituto Universitario de Química Organometálica Enrique Moles, University of Oviedo Julián Clavería 8 33006 Oviedo Spain
RSC Adv. 2025 May 8;15(19):15155-15163. doi: 10.1039/d5ra02540k. eCollection 2025 May 6.
Herein, a visible light-promoted metal-free protocol for the synthesis of nitrocyclopropanes under mild conditions is reported. Specifically, the process is driven by the photochemical activity of ternary EDA complexes formed upon complexation of α-bromonitrostyrenes and DIPEA in the presence of benzaldehyde. This reaction provides a variety of densely functionalized cyclopropanes with good selectivity under mild reaction conditions. Mechanistic investigations on the aspects of the process also demonstrate formation of the hypothesized EDA complex.
本文报道了一种在温和条件下可见光促进的无金属合成硝基环丙烷的方法。具体而言，该过程由α-溴硝基苯乙烯与二异丙基乙胺（DIPEA）在苯甲醛存在下络合形成的三元电子给体-受体（EDA）络合物的光化学活性驱动。该反应在温和的反应条件下提供了多种具有良好选择性的高度官能化环丙烷。对该过程各方面的机理研究也证实了假设的EDA络合物的形成。
