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核酸结合药物。第十三部分。药物 - 核酸模型系统中的分子运动：原黄素 - 二核苷晶体结构的热运动分析。

Nucleic acid binding drugs. Part XIII. Molecular motion in a drug-nucleic acid model system: thermal motion analysis of a proflavine-dinucleoside crystal structure.

作者信息

Aggarwal A K, Neidle S

出版信息

Nucleic Acids Res. 1985 Aug 12;13(15):5671-84. doi: 10.1093/nar/13.15.5671.

DOI:10.1093/nar/13.15.5671
PMID:4034394
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC321897/
Abstract

The high-resolution crystal structure of the intercalation complex between proflavine and cytidylyl-3',5'-guanosine (CpG) has been studied by thermalmotion analysis. This has provided information on the translational and librational motions of individual groups in the complex. Many of these motions are similar to, though of larger magnitude than in uncomplexed dinucleosides. Pronounced librational effects were observed along the base pairs and in the plane of the drug chromophore.

摘要

通过热运动分析研究了原黄素与胞苷-3',5'-鸟苷（CpG）插入复合物的高分辨率晶体结构。这提供了关于复合物中各个基团的平移和摆动运动的信息。其中许多运动与未复合的二核苷中的运动相似，只是幅度更大。沿着碱基对和药物发色团平面观察到了明显的摆动效应。

相似文献

1
Nucleic acid binding drugs. Part XIII. Molecular motion in a drug-nucleic acid model system: thermal motion analysis of a proflavine-dinucleoside crystal structure.核酸结合药物。第十三部分。药物 - 核酸模型系统中的分子运动：原黄素 - 二核苷晶体结构的热运动分析。
Nucleic Acids Res. 1985 Aug 12;13(15):5671-84. doi: 10.1093/nar/13.15.5671.
2
X-ray crystallographic analysis of a ternary intercalation complex between proflavine and the dinucleoside monophosphates CpA and UpG.对原黄素与二核苷酸单磷酸CpA和UpG之间的三元插层复合物进行X射线晶体学分析。
Biopolymers. 1984 Jun;23(6):1025-41. doi: 10.1002/bip.360230605.
3
[Determination of thermodynamic parameters of proflavine interaction with ribodinucleoside monophosphates CpG and PpC in an aqueous solution from data of proton magnetic resonance].
Mol Biol (Mosk). 1987 Jul-Aug;21(4):1110-6.
4
Crystallographic studies of drug-nucleic acid interactions: proflavine intercalation between the non-complementary base-pairs of cytidilyl-3',5'-adenosine.药物与核酸相互作用的晶体学研究：硫酸普罗黄素嵌入胞苷-3',5'-腺苷的非互补碱基对之间。
J Mol Biol. 1980 Sep 25;142(3):331-61. doi: 10.1016/0022-2836(80)90276-4.
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[Study of the interaction of proflavine and isomeric diribonucleoside monophosphates CpG and GpC by proton magnetic resonance].[通过质子磁共振研究硫酸原黄素与异构体二核糖核苷单磷酸CpG和GpC的相互作用]
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Ethidium cooperativity in the formation of complexes with CpG.溴化乙锭与CpG形成复合物时的协同性。
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Expression of the G6PD locus on the human X chromosome is associated with demethylation of three CpG islands within 100 kb of DNA.人类X染色体上G6PD基因座的表达与DNA 100 kb范围内三个CpG岛的去甲基化有关。
EMBO J. 1988 Feb;7(2):401-6. doi: 10.1002/j.1460-2075.1988.tb02827.x.
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Helix opening in deoxyribonucleic acid from a proton nuclear magnetic resonance study of imino and amino protons in d(CG)3.通过对d(CG)3中亚氨基和氨基质子的质子核磁共振研究得出的脱氧核糖核酸中的螺旋开口
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Infusion of imaging and therapeutic molecules into the plant virus-based carrier cowpea mosaic virus: cargo-loading and delivery.将成像和治疗分子注入基于植物病毒的载体豇豆花叶病毒：货物装载和输送。
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本文引用的文献

1
Structural considerations in the interaction of DNA and acridines.DNA与吖啶相互作用中的结构考量
J Mol Biol. 1961 Feb;3:18-30. doi: 10.1016/s0022-2836(61)80004-1.
2
The structure of drug-deoxydinucleoside phosphate complex; generalized conformational behavior of intercalation complexes with RNA and DNA fragments.药物-脱氧核苷磷酸复合物的结构；与RNA和DNA片段形成的嵌入复合物的一般构象行为。
Nucleic Acids Res. 1980 Jan 11;8(1):85-97. doi: 10.1093/nar/8.1.85.
3
Molecular mechanical studies of proflavine and acridine orange intercalation.硫酸原黄素和吖啶橙嵌入的分子力学研究。
Nucleic Acids Res. 1981 Mar 25;9(6):1483-97. doi: 10.1093/nar/9.6.1483.
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The interaction of intercalating drugs with nucleic acids.嵌入性药物与核酸的相互作用。
Annu Rev Biophys Bioeng. 1981;10:87-114. doi: 10.1146/annurev.bb.10.060181.000511.
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Molecular structure of an anticancer drug-DNA complex: daunomycin plus d(CpGpTpApCpG).一种抗癌药物 - DNA 复合物的分子结构：柔红霉素加 d(CpGpTpApCpG)
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7204-8. doi: 10.1073/pnas.77.12.7204.
6
X-ray crystallographic analysis of a ternary intercalation complex between proflavine and the dinucleoside monophosphates CpA and UpG.对原黄素与二核苷酸单磷酸CpA和UpG之间的三元插层复合物进行X射线晶体学分析。
Biopolymers. 1984 Jun;23(6):1025-41. doi: 10.1002/bip.360230605.
7
The molecular structure of a DNA-triostin A complex.一种DNA-三奥菌素A复合物的分子结构。
Science. 1984 Sep 14;225(4667):1115-21. doi: 10.1126/science.6474168.
8
Sequence-specific binding of echinomycin to DNA: evidence for conformational changes affecting flanking sequences.放线菌素与DNA的序列特异性结合：影响侧翼序列构象变化的证据。
Nucleic Acids Res. 1984 Jun 25;12(12):4865-79. doi: 10.1093/nar/12.12.4865.
9
Local mobility of nucleic acids as determined from crystallographic data. I. RNA and B form DNA.根据晶体学数据确定的核酸局部流动性。I. RNA和B型DNA。
J Mol Biol. 1984 Mar 5;173(3):361-88. doi: 10.1016/0022-2836(84)90126-8.
10
DNA modification and cancer.DNA修饰与癌症。
Annu Rev Biochem. 1981;50:159-92. doi: 10.1146/annurev.bi.50.070181.001111.