核酸结合药物。第十三部分。药物 - 核酸模型系统中的分子运动：原黄素 - 二核苷晶体结构的热运动分析。
Nucleic acid binding drugs. Part XIII. Molecular motion in a drug-nucleic acid model system: thermal motion analysis of a proflavine-dinucleoside crystal structure.
作者信息
Aggarwal A K, Neidle S
出版信息
Nucleic Acids Res. 1985 Aug 12;13(15):5671-84. doi: 10.1093/nar/13.15.5671.
Abstract
The high-resolution crystal structure of the intercalation complex between proflavine and cytidylyl-3',5'-guanosine (CpG) has been studied by thermalmotion analysis. This has provided information on the translational and librational motions of individual groups in the complex. Many of these motions are similar to, though of larger magnitude than in uncomplexed dinucleosides. Pronounced librational effects were observed along the base pairs and in the plane of the drug chromophore.
摘要
通过热运动分析研究了原黄素与胞苷-3',5'-鸟苷（CpG）插入复合物的高分辨率晶体结构。这提供了关于复合物中各个基团的平移和摆动运动的信息。其中许多运动与未复合的二核苷中的运动相似，只是幅度更大。沿着碱基对和药物发色团平面观察到了明显的摆动效应。
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