骨科住院患者锌缺乏的决定因素。
Determinant of zinc deficiency in orthopaedic inpatients.
作者信息
Iida Daisuke, Shigemura Tomonori, Yamamoto Yohei, Morimoto Miki, Murata Yasuaki
机构信息
Department of Orthopaedic Surgery, Teikyo University Chiba Medical Center, Ichihara, Chiba, Japan.
出版信息
PLoS One. 2025 May 9;20(5):e0322142. doi: 10.1371/journal.pone.0322142. eCollection 2025.
Zinc is vital for over 300 enzymes in major metabolic pathways, and deficiency can lead to serious conditions, especially post-surgery. This study aimed to investigate predictive factors of zinc deficiency in orthopaedic inpatients. A retrospective case-control study was conducted on patients admitted to Teikyo University Chiba Medical Center from 15 February to 31 August 2022. Patients were divided into zinc deficiency (< 60 µg/dL) and non-deficiency groups. Data included demographics, comorbidities, hospitalisation reasons, fracture details, medication use, and laboratory values. Fisher's exact test and two-sample t-tests were used for analysis. Of 156 patients, 47 (30.1%) had zinc deficiency. The case group had higher fracture rates (68.1% vs. 33.9%; p < 0.001), and lower rates of spinal disease (2.1% vs. 31.2%; p < 0.001) and osteoarthritis (8.5% vs. 22.9%; p = 0.04). Fragility and hip fractures were more common in the case group. Anaemia, hip fracture, and hypoalbuminaemia were independent predictive factors of zinc deficiency.
锌对主要代谢途径中的300多种酶至关重要，锌缺乏会导致严重疾病，尤其是在手术后。本研究旨在调查骨科住院患者锌缺乏的预测因素。对2022年2月15日至8月31日入住帝京大学千叶医疗中心的患者进行了一项回顾性病例对照研究。患者被分为锌缺乏组（<60µg/dL）和非缺乏组。数据包括人口统计学、合并症、住院原因、骨折细节、用药情况和实验室检查值。采用Fisher精确检验和两样本t检验进行分析。156例患者中，47例（30.1%）存在锌缺乏。病例组骨折发生率较高（68.1%对33.9%；p<0.001），脊柱疾病（2.1%对31.2%；p<0.001）和骨关节炎（8.5%对22.9%；p=0.04）发生率较低。病例组中脆性骨折和髋部骨折更为常见。贫血、髋部骨折和低白蛋白血症是锌缺乏的独立预测因素。
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