实验性动脉粥样硬化模型的探索：家兔、豚鼠和大鼠的比较研究
A search for a model of experimental atherosclerosis: comparative studies in rabbits, guinea pigs and rats.
作者信息
Wójcicki J, Samochowiec L, Jaworska M, Hinek A
出版信息
Pol J Pharmacol Pharm. 1985 Jan-Feb;37(1):11-21.
Rabbits, guinea pigs and rats received for 3 months a high lipid diet containing coconut oil and cholesterol, separately or in combination. The blood lipid content was assayed. Lipoproteins were separated into fractions by agarose electrophoresis. The aorta, heart and liver were investigated macro- and microscopically. The most pronounced changes in lipid metabolism appeared as a consequence of combined administration of coconut oil and cholesterol; they were most expressed in rabbits, less in guinea pigs, and most weakly in rats. Typical atherosclerotic lesions were observed only in rabbit's aorta. They were accompanied by a marked depression of the percentage content of alpha-lipoproteins in blood serum.
兔子、豚鼠和大鼠分别或联合接受为期3个月的含椰子油和胆固醇的高脂饮食。检测血脂含量。通过琼脂糖电泳将脂蛋白分离成不同组分。对主动脉、心脏和肝脏进行大体和显微镜检查。脂质代谢最明显的变化是椰子油和胆固醇联合给药的结果；这些变化在兔子中表现最为明显，在豚鼠中次之，在大鼠中最不明显。仅在兔子的主动脉中观察到典型的动脉粥样硬化病变。它们伴随着血清中α-脂蛋白百分比含量的显著降低。
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