Bozhko G Kh, Kostiukovs'ka L S, Kulabukhov V M, Voloshyn P V
Ukr Biokhim Zh (1978). 1990 Sep-Oct;62(5):25-9.
The hypercholesteremia parameters under similar experimental conditions against a background of the close initial level of cholesterol were considerably more expressed in rabbits than in guinea pigs. Rabbits showed clear symptoms of experimental atherosclerosis which were absent in guinea pigs. A comparative study of quantitative and composition variations in total proteins of the serum and fraction obtained by acid extraction indicated that the differences in dynamics and degree of cholesterinosis were expressed by features of the serum protein spectrum variation in the investigated kinds of animals. Especially close relation has been observed for the fraction components of acid-extracted proteins. The obtained results permit supposing that some kinds of animals have mechanisms connected with the function of the serum alkaline proteins preventing the development of hypercholesteremia and experimental atherosclerosis.
在相似实验条件下，在胆固醇初始水平相近的背景下，家兔的高胆固醇血症参数比豚鼠表现得更为明显。家兔出现了明显的实验性动脉粥样硬化症状，而豚鼠没有。对血清总蛋白及酸提取所得组分的定量和成分变化进行的比较研究表明，在所研究的动物种类中，胆固醇沉着症的动态变化和程度差异通过血清蛋白谱变化特征表现出来。对于酸提取蛋白的组分，观察到了特别密切的关系。所得结果使人推测，某些动物种类具有与血清碱性蛋白功能相关的机制，可预防高胆固醇血症和实验性动脉粥样硬化的发展。
