Verrillo M, Pantina V D, Venezia V, Modica C, Lo Iacono M, Bianca P, Bozzari G, Angeloro F, Cozzolino V, Stassi G, Spaccini R
Department of Agricultural Sciences, University of Naples Federico II, Portici, Naples, Italy.
Department of Precision Medicine in Medical, Surgical and Critical Care, University of Palermo, Palermo 90100, Italy.
Pharmacol Res. 2025 Jun;216:107740. doi: 10.1016/j.phrs.2025.107740. Epub 2025 May 7.
Natural byproducts have garnered significant attention for their potential antitumorigenic properties. The current scenario sketched by the goals of circular economy approaches the research towards the utilization of agro-waste biomasses as valuable source of biological active metabolites. This comprehensive scientific review explores the various mechanisms through which these natural compounds exert anticancer effects, including apoptosis induction, cell cycle arrest, inhibition of angiogenesis, and suppression of metastasis. The review highlights key bioactive molecules such as polyphenols, flavonoids, alkaloids, and terpenoids, examining their molecular interactions with cancer cells. Furthermore, the potential of these natural byproducts as adjuvant therapies in combination with conventional treatments is discussed. By summarizing recent advancements and identifying future research directions, this review underscores the promise of natural byproducts from as a source of novel anticancer agents. A specific section is dedicated to outline the role of innovative materials, such as nanoparticles, hydrogels, and biopolymers, that are being developed to enhance the delivery and efficacy of active components. These carriers offer improved stability, targeted delivery, and controlled release of natural compounds, maximizing their therapeutic potential while minimizing side effects.
天然副产品因其潜在的抗肿瘤特性而备受关注。循环经济目标所勾勒的当前情形推动了对将农业废弃物生物质作为生物活性代谢物宝贵来源加以利用的研究。这篇全面的科学综述探讨了这些天然化合物发挥抗癌作用的各种机制，包括诱导细胞凋亡、使细胞周期停滞、抑制血管生成以及抑制转移。该综述重点介绍了关键的生物活性分子，如多酚、黄酮类化合物、生物碱和萜类化合物，研究了它们与癌细胞的分子相互作用。此外，还讨论了这些天然副产品作为辅助疗法与传统治疗方法联合使用的潜力。通过总结近期进展并确定未来研究方向，本综述强调了天然副产品作为新型抗癌剂来源的前景。一个特定部分专门概述了创新材料的作用，如纳米颗粒、水凝胶和生物聚合物，这些材料正在被开发以提高活性成分的递送和疗效。这些载体提高了天然化合物的稳定性、靶向递送和控释能力，在将其治疗潜力最大化的同时将副作用最小化。
