Johannigmann-Malek Navid, Coulibaly Leonard, Groselli Sofia, Gabka Katharina, Charbel Issa Peter, Baumann Carmen
Department of Ophthalmology, TUM University Hospital, Technical University of Munich (TUM), School of Medicine and Health, Munich, Germany.
Department of Ophthalmology, TUM University Hospital, Technical University of Munich (TUM), School of Medicine and Health, Munich, Germany
BMJ Open Ophthalmol. 2025 May 8;10(1):e002131. doi: 10.1136/bmjophth-2024-002131.
To assess the interchangeability of minimum linear diameter (MLD) macular hole (MH) size measurements in high-density horizontal and radial scan modes in optical coherence tomography (OCT).
60 patients with a MH had repeat high-density OCT volume scans in a horizontal (30 µm interscan-spacing) and a radial (angular 3.75° interscan-spacing) mode, and the MLD was measured by five raters.
There were no significant differences in the MLD measurements within the horizontal and the radial modes across repeat measurements of each rater in volume scan 1 (all p≥0.14 and p≥0.28, respectively), between volume scans 1 and 2 (all p≥0.14 and p≥0.69), among the raters (p=0.70 and p=0.60), and using all MLD measurements obtained in this study between primary and repeat measurements in volume scan 1 (p=0.10 and p=0.74) and between measurements obtained in volume scan 1 and 2 (p=0.21 and p=0.90).There was a statistically significant difference of -10.05 µm between the mean MLD of all measurements in the horizontal (n=900) and in the radial (n=900) mode (427.91 (±187.01) vs 437.97 (±184.93) µm; p<0.001). However, the variability of these differences around the mean MLD was large (95% limits of agreement -77.31 to 57.21 µm). The mean difference between all horizontal and all radial MLD measurements in a MH was for MHs that had their widest MLD within 15° of the horizontal, vertical and diagonal meridians 0.77 (±13.88) µm, -34.43 (±55.22) µm and -10.39 (± 34.62) µm, respectively.
Horizontal scans systematically underestimate the maximum MLD if located vertically or diagonally; however, they have less intra-rater and inter-rater and inter-scan variability in MLD measurements as compared with radial scans. Therefore, the two scan modes are not interchangeable but rather complement each other. These results may be limited to the MLD range analysed (125-924 µm).
评估光学相干断层扫描（OCT）中高密度水平扫描模式和径向扫描模式下黄斑裂孔（MH）最小线性直径（MLD）测量值的互换性。
60例MH患者分别在水平（扫描间距30 µm）和径向（扫描间距角3.75°）模式下进行重复的高密度OCT容积扫描，由5名评估者测量MLD。
在第1次容积扫描中，每位评估者的重复测量中，水平模式和径向模式下的MLD测量值无显著差异（所有p值分别≥0.14和≥0.28），第1次和第2次容积扫描之间也无显著差异（所有p值分别≥0.14和≥0.69），评估者之间无显著差异（p = 0.70和p = 0.60），并且使用本研究中获得的所有MLD测量值，第1次容积扫描的初次测量和重复测量之间无显著差异（p = 0.10和p = 0.74），第1次和第2次容积扫描的测量值之间也无显著差异（p = 0.21和p = 0.90）。水平模式（n = 900）和径向模式（n = 900）下所有测量值的平均MLD之间存在-10.05 µm的统计学显著差异（分别为427.91（±187.01）与437.97（±184.93）µm；p < 0.001）。然而，这些差异围绕平均MLD的变异性很大（一致性界限的95%为-77.31至57.21 µm）。对于MLD最宽处位于水平、垂直和对角子午线15°范围内的MH，所有水平和所有径向MLD测量值之间的平均差异分别为0.77（±13.88）µm、-34.43（±55.22）µm和-10.39（±34.62）µm。
如果MH位于垂直或对角方向，水平扫描会系统性地低估最大MLD；然而，与径向扫描相比，水平扫描在MLD测量中的评估者内、评估者间和扫描间变异性较小。因此，这两种扫描模式不可互换，而是相互补充。这些结果可能仅限于所分析的MLD范围（125 - 924 µm）。
