Backman Emelie, Gröning Remigius, Lind Alicia, Granvik Christoffer, Eilers Hinnerk, Lange Anna, Ahlm Clas, Cajander Sara, Forsell Mattias N E, Normark Johan, Urban Constantin F
Department of Clinical Microbiology, Umeå University, Umeå, Sweden.
Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden.
Eur J Immunol. 2025 May;55(5):e202451546. doi: 10.1002/eji.202451546.
Severe COVID-19 disease is accompanied by high plasma levels of proinflammatory, prothrombotic NETs, and NET-inducing cytokine IL-18. We found that both, IL-18 and NETs, are elevated in men with severe disease, but not in women of the same category. Our findings warrant further investigation of sex-related differences in SARS-CoV-2 infection.
重症新冠肺炎伴有血浆中促炎、促血栓形成的中性粒细胞胞外陷阱（NETs）以及诱导NETs的细胞因子白细胞介素-18（IL-18）水平升高。我们发现，IL-18和NETs在重症男性患者中均升高，但在同类型的女性患者中则不然。我们的研究结果值得进一步探究新冠病毒感染中与性别相关的差异。
