Limban Carmen, Nuță Diana Camelia, Caproiu Miron Teodor, Dumitrescu Denisa Elena, Papacocea Șerban Iancu, Bordei Alexandra Teodora, Dumitrașcu Florea
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
"C.D. Nenitzescu" Institute of Organic and Supramolecular Chemistry of Romanian Academy, Bucharest, Romania.
Chem Biol Drug Des. 2025 May;105(5):e70122. doi: 10.1111/cbdd.70122.
Carprofen, a nonsteroidal anti-inflammatory drug (NSAID) derived from propanoic acid, is known for its analgesic and antipyretic properties. Although it has long been employed in veterinary medicine as an anti-inflammatory agent, its use in humans was discontinued shortly after its market launch due to costly raw materials, complex synthesis, and labor-intensive production processes-factors that made it less competitive compared with other NSAIDs. Despite this, the carprofen molecule remains a subject of significant scientific interest. Recent advancements in its synthesis have introduced simplified and more cost-effective methods, reigniting its potential for both novel applications and drug repurposing. Exciting new research is exploring carprofen's broader therapeutic possibilities, extending beyond its original anti-inflammatory role. Studies are investigating its efficacy in antimicrobial therapy-including antibiofilm, anticancer, antiviral, and anti-Alzheimer's applications-opening doors to a wealth of untapped possibilities. This review delves into these emerging areas, highlighting how carprofen's molecular structure and derivatives can be leveraged to expand its therapeutic reach. The literature review was conducted using four databases: Web of Science, ScienceDirect, Scopus, Embase, and Reaxys. The review focused on English-language original research and review articles, examining carprofen and its derivatives in terms of their synthesis methods as well as their use as small molecules in various therapeutic applications, both human and veterinary. With ongoing research pushing the boundaries of its potential, carprofen remains a promising candidate for innovation in drug development and treatment strategies.
卡洛芬是一种源自丙酸的非甾体抗炎药（NSAID），以其镇痛和解热特性而闻名。尽管它长期以来一直被用作兽用抗炎药，但由于原材料成本高、合成复杂以及生产过程劳动密集，在上市后不久就停止了在人类中的使用，这些因素使其与其他NSAID相比缺乏竞争力。尽管如此，卡洛芬分子仍然是重大科学兴趣的主题。其合成方面的最新进展引入了更简化、更具成本效益的方法，重新点燃了其在新应用和药物重新利用方面的潜力。令人兴奋的新研究正在探索卡洛芬更广泛的治疗可能性，超出其最初的抗炎作用。研究正在调查其在抗菌治疗中的功效，包括抗生物膜、抗癌、抗病毒和抗阿尔茨海默病应用，为大量未开发的可能性打开了大门。本综述深入探讨这些新兴领域，强调如何利用卡洛芬的分子结构和衍生物来扩大其治疗范围。文献综述使用了四个数据库：科学网、科学Direct、Scopus、Embase和Reaxys。该综述侧重于英语原创研究和综述文章，从合成方法以及作为小分子在各种人类和兽用治疗应用中的用途方面研究卡洛芬及其衍生物。随着持续的研究不断拓展其潜力边界，卡洛芬仍然是药物开发和治疗策略创新的有希望的候选者。
