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1
Xenon in ALS Treatment: What Are We Waiting for?氙气用于肌萎缩侧索硬化症治疗:我们还在等什么?
CNS Neurosci Ther. 2025 May;31(5):e70435. doi: 10.1111/cns.70435.
2
Xenon arc photocoagulation of proliferative diabetic retinopathy (a review of 2688 consecutive eyes in the format of the diabetic retinopathy study--DRS).增殖性糖尿病视网膜病变的氙弧光凝术(以糖尿病视网膜病变研究——DRS的形式对2688只连续眼进行的回顾)
Trans Am Ophthalmol Soc. 1983;81:229-45.
3
Attenuated iron stress and oxidative stress may participate in anti-seizure and neuroprotective roles of xenon in pentylenetetrazole-induced epileptogenesis.减轻的铁应激和氧化应激可能参与了氙气在戊四氮诱导癫痫发生过程中的抗癫痫和神经保护作用。
Front Cell Neurosci. 2022 Nov 17;16:1007458. doi: 10.3389/fncel.2022.1007458. eCollection 2022.
4
Xenon arc photocoagulation of proliferative diabetic retinopathy. A review of 2688 consecutive eyes in the format of the Diabetic Retinopathy Study.增殖性糖尿病视网膜病变的氙弧光凝术。以糖尿病视网膜病变研究的形式对2688只连续眼进行的回顾。
Ophthalmology. 1984 Dec;91(12):1458-63. doi: 10.1016/s0161-6420(84)34122-7.
5
Potential application value of xenon in stroke treatment.氙气在中风治疗中的潜在应用价值。
Med Gas Res. 2018 Sep 25;8(3):116-120. doi: 10.4103/2045-9912.241077. eCollection 2018 Jul-Sep.
6
Xenon improves neurologic outcome and reduces secondary injury following trauma in an in vivo model of traumatic brain injury.在创伤性脑损伤的体内模型中,氙气可改善神经功能转归并减轻创伤后的继发性损伤。
Crit Care Med. 2015 Jan;43(1):149-158. doi: 10.1097/CCM.0000000000000624.
7
Xenon treatment after severe traumatic brain injury improves locomotor outcome, reduces acute neuronal loss and enhances early beneficial neuroinflammation: a randomized, blinded, controlled animal study.氙气治疗严重创伤性脑损伤可改善运动功能,减少急性神经元丢失,增强早期有益的神经炎症:一项随机、盲法、对照动物研究。
Crit Care. 2020 Nov 27;24(1):667. doi: 10.1186/s13054-020-03373-9.
8
Repetitive xenon treatment improves post-stroke sensorimotor and neuropsychiatric dysfunction.重复氙气处理可改善卒中后感觉运动和神经精神功能障碍。
J Affect Disord. 2022 Mar 15;301:315-330. doi: 10.1016/j.jad.2022.01.025. Epub 2022 Jan 4.
9
Xenon Blocks Neuronal Injury Associated with Decompression.氙气可阻止与减压相关的神经元损伤。
Sci Rep. 2015 Oct 15;5:15093. doi: 10.1038/srep15093.
10
The neuroprotective effect and possible therapeutic application of xenon in neurological diseases.氙气在神经系统疾病中的神经保护作用及可能的治疗应用。
J Neurosci Res. 2021 Dec;99(12):3274-3283. doi: 10.1002/jnr.24958. Epub 2021 Oct 29.

本文引用的文献

1
Xenon treatment after severe traumatic brain injury improves locomotor outcome, reduces acute neuronal loss and enhances early beneficial neuroinflammation: a randomized, blinded, controlled animal study.氙气治疗严重创伤性脑损伤可改善运动功能,减少急性神经元丢失,增强早期有益的神经炎症:一项随机、盲法、对照动物研究。
Crit Care. 2020 Nov 27;24(1):667. doi: 10.1186/s13054-020-03373-9.
2
Impairment of Mitochondrial Calcium Buffering Links Mutations in C9ORF72 and TARDBP in iPS-Derived Motor Neurons from Patients with ALS/FTD.线粒体钙缓冲功能障碍将 C9ORF72 和 TARDBP 突变联系起来,导致 ALS/FTD 患者的 iPS 衍生运动神经元损伤。
Stem Cell Reports. 2020 May 12;14(5):892-908. doi: 10.1016/j.stemcr.2020.03.023. Epub 2020 Apr 23.
3
Experimental approaches for elucidating co-agonist regulation of NMDA receptor in motor neurons: Therapeutic implications for amyotrophic lateral sclerosis (ALS).阐明运动神经元中NMDA受体共激动剂调节作用的实验方法:对肌萎缩侧索硬化症(ALS)的治疗意义
J Pharm Biomed Anal. 2015 Dec 10;116:2-6. doi: 10.1016/j.jpba.2014.12.040. Epub 2015 Jan 3.
4
Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia.氙气与低温相结合可对新生儿窒息起到神经保护作用。
Ann Neurol. 2005 Aug;58(2):182-93. doi: 10.1002/ana.20547.
5
Xenon reduces glutamate-, AMPA-, and kainate-induced membrane currents in cortical neurones.氙气可降低皮质神经元中谷氨酸、α-氨基-3-羟基-5-甲基-4-异恶唑丙酸和海人藻酸诱导的膜电流。
Br J Anaesth. 2005 Apr;94(4):479-85. doi: 10.1093/bja/aei080. Epub 2005 Feb 4.
6
Reduction of ischemic brain damage by nitrous oxide and xenon.一氧化二氮和氙气对缺血性脑损伤的减轻作用
J Cereb Blood Flow Metab. 2003 Oct;23(10):1168-73. doi: 10.1097/01.WCB.0000087342.31689.18.
7
Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat.氙气可减轻大鼠体外循环引起的神经和神经认知功能障碍。
Anesthesiology. 2003 Mar;98(3):690-8. doi: 10.1097/00000542-200303000-00017.
8
How does xenon produce anaesthesia?
Nature. 1998 Nov 26;396(6709):324. doi: 10.1038/24525.
9
NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones.N-甲基-D-天冬氨酸受体激活可增加培养脊髓神经元中的细胞质钙浓度。
Nature. 1986;321(6069):519-22. doi: 10.1038/321519a0.
10
Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis.肌萎缩侧索硬化症中脑和脊髓谷氨酸转运减少。
N Engl J Med. 1992 May 28;326(22):1464-8. doi: 10.1056/NEJM199205283262204.

Xenon in ALS Treatment: What Are We Waiting for?

作者信息

Çelik Ferhat

机构信息

Dicle University, Atatürk Vocational School of Health Services, Diyarbakir, Turkey.

出版信息

CNS Neurosci Ther. 2025 May;31(5):e70435. doi: 10.1111/cns.70435.

DOI:10.1111/cns.70435
PMID:40346952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12064941/
Abstract
摘要