Xenon in ALS Treatment: What Are We Waiting for?
作者信息
Çelik Ferhat
机构信息
Dicle University, Atatürk Vocational School of Health Services, Diyarbakir, Turkey.
出版信息
CNS Neurosci Ther. 2025 May;31(5):e70435. doi: 10.1111/cns.70435.
Abstract
摘要
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Xenon in ALS Treatment: What Are We Waiting for?氙气用于肌萎缩侧索硬化症治疗：我们还在等什么？
CNS Neurosci Ther. 2025 May;31(5):e70435. doi: 10.1111/cns.70435.
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本文引用的文献
1
Xenon treatment after severe traumatic brain injury improves locomotor outcome, reduces acute neuronal loss and enhances early beneficial neuroinflammation: a randomized, blinded, controlled animal study.氙气治疗严重创伤性脑损伤可改善运动功能，减少急性神经元丢失，增强早期有益的神经炎症：一项随机、盲法、对照动物研究。
Crit Care. 2020 Nov 27;24(1):667. doi: 10.1186/s13054-020-03373-9.
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Impairment of Mitochondrial Calcium Buffering Links Mutations in C9ORF72 and TARDBP in iPS-Derived Motor Neurons from Patients with ALS/FTD.线粒体钙缓冲功能障碍将 C9ORF72 和 TARDBP 突变联系起来，导致 ALS/FTD 患者的 iPS 衍生运动神经元损伤。
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Experimental approaches for elucidating co-agonist regulation of NMDA receptor in motor neurons: Therapeutic implications for amyotrophic lateral sclerosis (ALS).阐明运动神经元中NMDA受体共激动剂调节作用的实验方法：对肌萎缩侧索硬化症（ALS）的治疗意义
J Pharm Biomed Anal. 2015 Dec 10;116:2-6. doi: 10.1016/j.jpba.2014.12.040. Epub 2015 Jan 3.
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Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia.氙气与低温相结合可对新生儿窒息起到神经保护作用。
Ann Neurol. 2005 Aug;58(2):182-93. doi: 10.1002/ana.20547.
5
Xenon reduces glutamate-, AMPA-, and kainate-induced membrane currents in cortical neurones.氙气可降低皮质神经元中谷氨酸、α-氨基-3-羟基-5-甲基-4-异恶唑丙酸和海人藻酸诱导的膜电流。
Br J Anaesth. 2005 Apr;94(4):479-85. doi: 10.1093/bja/aei080. Epub 2005 Feb 4.
6
Reduction of ischemic brain damage by nitrous oxide and xenon.一氧化二氮和氙气对缺血性脑损伤的减轻作用
J Cereb Blood Flow Metab. 2003 Oct;23(10):1168-73. doi: 10.1097/01.WCB.0000087342.31689.18.
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Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat.氙气可减轻大鼠体外循环引起的神经和神经认知功能障碍。
Anesthesiology. 2003 Mar;98(3):690-8. doi: 10.1097/00000542-200303000-00017.
8
How does xenon produce anaesthesia?
Nature. 1998 Nov 26;396(6709):324. doi: 10.1038/24525.
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NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones.N-甲基-D-天冬氨酸受体激活可增加培养脊髓神经元中的细胞质钙浓度。
Nature. 1986;321(6069):519-22. doi: 10.1038/321519a0.
10
Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis.肌萎缩侧索硬化症中脑和脊髓谷氨酸转运减少。
N Engl J Med. 1992 May 28;326(22):1464-8. doi: 10.1056/NEJM199205283262204.
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