Mackinnon S E, Dellon A L, Hudson A R, Hunter D A
Plast Reconstr Surg. 1985 Sep;76(3):345-53. doi: 10.1097/00006534-198509000-00001.
In a primate model a histologic assessment of neuroma formation is reported. Three experimental groups were defined. Transected sensory nerves left adjacent to the incisional wound in an area of movement (wrist) were considered the control group. In the "proximally cut" group the same sensory nerves were positioned well proximal to the incisional wound. In the "muscle-implantation" group these nerves were placed in adjacent muscles. At 6 months a histologic assessment of the neuroma formation in the three experimental groups was carried out. Implantation of the sensory nerve into muscle significantly altered the regenerative potential of that nerve. The muscle completely surrounded the sensory nerve. The minimal neuroma that formed had significantly less scar tissue and contained nerve fibers that were of a smaller diameter and decreased density than either the control or the proximally cut group. There were no histologic differences between these latter two groups. However, regeneration into the overlying skin that was noted in the control neuromas was not seen in those nerves which had been proximally cut.
在一个灵长类动物模型中，报道了对神经瘤形成的组织学评估。定义了三个实验组。在运动区域（腕部）靠近切口伤口处切断并留下的感觉神经被视为对照组。在“近端切断”组中，相同的感觉神经被放置在切口伤口近端的合适位置。在“肌肉植入”组中，这些神经被放置在相邻肌肉中。在6个月时，对三个实验组中神经瘤的形成进行了组织学评估。将感觉神经植入肌肉显著改变了该神经的再生潜能。肌肉完全包围了感觉神经。形成的最小神经瘤瘢痕组织明显较少，并且与对照组或近端切断组相比，所含神经纤维直径更小、密度更低。后两组之间没有组织学差异。然而，在近端切断的神经中未观察到对照组神经瘤中出现的向覆盖皮肤的再生情况。
