Oral and Maxillofacial Surgery Department. Hospital Universitario Miguel Servet.
Growth, Exercise, Nutrition and Development (GENUD) Research Group. Instituto Agroalimentario de Aragón (IA2). Universidad de Zaragoza.
Nutr Hosp. 2021 Apr 19;38(2):410-417. doi: 10.20960/nh.03426.
Introduction: in children with cleft lip and/or palate nutritional status and growth may be impaired due to early life feeding difficulties. Objective: to review the existing literature on the nutritional prognosis during childhood of patients undergoing surgery for cleft lip and/or palate (CLP), their body composition and growth patterns from 2 to 10 years of age, and the possible effects of their early nutritional status on the long-term onset of overweight. Methods: a systematic search of growth and body composition parameters in 2-10 year-old CLP children, including cross-sectional and longitudinal studies, and using the Pubmed and Scopus databases. From the 2,983 retrieved articles, 6 were finally included. Results: two studies out of 6 were longitudinal and the other 4 were cross-sectional, including very heterogeneous samples. Weight and height were used as growth parameters in 2 studies; 2 studies used body mass index (BMI); and the remaining 2 used indexes of nutritional status derived from anthropometric measures. The studies showed discrepancies among results: 3 of them found growth differences between children with CLP and their counterparts, whereas the other 3 did not. The two longitudinal studies did not show any significant differences between the mean BMI z-scores or growth curves of cleft patients and their counterparts. When differences existed, the most affected group was that under 5 years, syndromic children, and adopted children with CL/P. Conclusions: the literature is scarce comparing growth patterns between children with CLP and controls, and results cannot confirm that children with CLP aged 2-10 years, excluding those with syndromes or belonging to vulnerable populations, have different growth patterns or a worse nutritional status than their counterparts.
唇腭裂患儿由于早期喂养困难，可能存在营养状况和生长受损。目的：回顾唇腭裂（CLP）患儿手术治疗后 2 至 10 岁期间的营养预后、身体成分和生长模式的现有文献，并评估其早期营养状况对超重长期发病的可能影响。方法：通过 Pubmed 和 Scopus 数据库，对 2 至 10 岁 CLP 患儿的生长和身体成分参数进行系统检索，包括横断面和纵向研究。共检索到 2983 篇文章，最终纳入 6 篇。结果：6 篇研究中有 2 篇为纵向研究，4 篇为横断面研究，样本差异较大。2 项研究将体重和身高作为生长参数；2 项研究使用了体质指数（BMI）；其余 2 项研究使用了基于人体测量指标的营养状况指数。研究结果存在差异：3 项研究发现唇腭裂患儿与对照组之间存在生长差异，而另外 3 项研究未发现差异。2 项纵向研究未发现唇腭裂患儿和对照组的平均 BMI z 评分或生长曲线有显著差异。当存在差异时，受影响最大的是 5 岁以下的患儿、综合征患儿和被收养的唇腭裂患儿。结论：目前比较唇腭裂患儿和对照组生长模式的文献较少，结果无法证实 2 至 10 岁的唇腭裂患儿（不包括综合征患儿或弱势群体）的生长模式或营养状况与对照组存在差异。
