Machado Mizael, Ciuffo Camila, Giannitti Federico, Silveira Caroline da Silva, Perdomo Yisell, Queiroz-Machado Cintia R R, Carriquiry Rafael, Zarantonelli Leticia, Menchaca Alejo
Instituto Nacional de Investigación Agropecuaria, Tacuarembó, Uruguay.
Unidad Mixta Pasteur + INIA, Institut Pasteur, Montevideo, Uruguay.
J Vet Diagn Invest. 2025 May 12:10406387251341234. doi: 10.1177/10406387251341234.
is an emerging human and animal pathogen. Here we describe 2 unrelated outbreaks of acute fatal leptospirosis caused by in suckling lambs and calves diagnosed following a flooding event in the spring of 2023 in northern Uruguay. In outbreak 1, the sheep flock was raised in a low-lying area previously used for rice cultivation; 20 lambs died after developing apathy, jaundice, and hemoglobinuria. In outbreak 2, 2 calves were found dead. At autopsy, 4 lambs and 2 calves had marked jaundice, hemoglobinuria, dark-red kidneys, and hepatomegaly. Microscopically, we found marked hemoglobinuric nephrosis, lymphohistiocytic tubulointerstitial nephritis, hepatocellular dissociation, and random hepatocellular necrosis with periportal lymphohistiocytic hepatitis and canalicular cholestasis. Positive immunostaining for sp. was found in the liver (lamb C), both the liver and kidney (calf B), and the liver (calf A). was PCR-confirmed using kidney and liver samples from the autopsied animals. Acute leptospirosis caused by has not been reported previously in sheep and cattle, to our knowledge. Our findings highlight that infection can cause acute leptospirosis in unvaccinated lambs and calves.
是一种新出现的人畜共患病原体。在此，我们描述了2023年春季乌拉圭北部发生洪水事件后，在哺乳羔羊和犊牛中由引起的两起不相关的急性致命钩端螺旋体病疫情。在疫情1中，羊群饲养在以前用于种植水稻的低洼地区；20只羔羊在出现冷漠、黄疸和血红蛋白尿后死亡。在疫情2中，发现2头犊牛死亡。尸检时，4只羔羊和2头犊牛有明显黄疸、血红蛋白尿、暗红色肾脏和肝肿大。显微镜下，我们发现明显的血红蛋白尿性肾病、淋巴细胞组织细胞性肾小管间质性肾炎、肝细胞解离以及随机的肝细胞坏死伴门周淋巴细胞组织细胞性肝炎和胆小管胆汁淤积。在肝脏（羔羊C）、肝脏和肾脏（犊牛B）以及肝脏（犊牛A）中发现针对sp.的阳性免疫染色。使用尸检动物的肾脏和肝脏样本通过PCR确认了。据我们所知，以前在绵羊和牛中尚未报道过由引起的急性钩端螺旋体病。我们的研究结果强调，感染可在未接种疫苗的羔羊和犊牛中引起急性钩端螺旋体病。
