Hay J G, Geddes D M
Thorax. 1985 Jul;40(7):493-6. doi: 10.1136/thx.40.7.493.
In cystic fibrosis the potential difference between interstitial fluid and the surface of respiratory and sweat duct epithelia is abnormally large. This study attempted to confirm this finding and investigate its value for a diagnostic test. With a subcutaneous reference electrode the mean potential difference of the inferior turbinate was -25 mv in 19 patients with cystic fibrosis, which was significantly greater than the difference of -13 mv in 22 normal subjects (p less than 0.02). Of the observations in the patients with cystic fibrosis, 67% were greater than the largest potential difference observed in normal individuals. Potential differences from the lip and forearm were also significantly greater in cystic fibrosis than in normal subjects, but there was considerable overlap. Changes in the electrical properties of nasal epithelium and skin have been confirmed in cystic fibrosis, but these have limited use for diagnosis.
在囊性纤维化中，间质液与呼吸道及汗腺导管上皮表面之间的电位差异常大。本研究试图证实这一发现，并探讨其在诊断试验中的价值。使用皮下参考电极，19例囊性纤维化患者下鼻甲的平均电位差为-25毫伏，显著大于22例正常受试者-13毫伏的差值（p小于0.02）。在囊性纤维化患者的观察结果中，67%大于正常个体观察到的最大电位差。囊性纤维化患者唇部和前臂的电位差也显著大于正常受试者，但存在相当大的重叠。囊性纤维化患者鼻上皮和皮肤的电学性质变化已得到证实，但这些变化在诊断中的应用有限。
