Alsuwaidan S, Li Wan Po A, Morrison G, Redmond A, Dodge J A, McElnay J, Stewart E, Stanford C F
School of Pharmacy, Queen's University of Belfast, UK.
Thorax. 1994 Dec;49(12):1249-50. doi: 10.1136/thx.49.12.1249.
Normal subjects have a negative nasal transmucosal potential difference (TPD) at rest which becomes more negative with exercise. Patients with cystic fibrosis have a more negative resting nasal TPD than controls. The present study was designed to determine the effects of exercise on the TPD of patients with cystic fibrosis.
Seven subjects with cystic fibrosis and seven control subjects had their usual TPD measured at rest, and during and after a 12 minute period on an exercise bicycle designed to produce a pulse rate of 80% of their maximum predicted value.
The normal subjects developed a more negative nasal TPD during exercise which returned towards normal at the completion of the rest period. The patients with cystic fibrosis had higher resting values which became less negative during exercise. At the end of the exercise period there was no difference between the two groups. At the end of the recovery period the results for the patients with cystic fibrosis had returned to their resting values.
Exercise reduces the abnormally high resting values for nasal TPD in patients with cystic fibrosis. Elucidation of the mechanism for this change may help to produce functional improvement for patients with this disease.
正常受试者静息时鼻黏膜跨膜电位差（TPD）为负值，运动时该值变得更负。囊性纤维化患者静息时的鼻TPD比对照组更负。本研究旨在确定运动对囊性纤维化患者TPD的影响。
7名囊性纤维化患者和7名对照受试者在静息时、在旨在使心率达到其最大预测值80%的健身自行车上运动12分钟期间及运动后，测量其通常的TPD。
正常受试者运动期间鼻TPD变得更负，在休息期结束时恢复至正常。囊性纤维化患者静息值较高，运动时变得不那么负。运动期结束时两组之间无差异。恢复期结束时，囊性纤维化患者的结果恢复至其静息值。
运动可降低囊性纤维化患者鼻TPD异常高的静息值。阐明这种变化的机制可能有助于改善该疾病患者的功能。
