Saygin Didem, Malfait Anne-Marie, Ritz Ethan M, Wipfler Kristin, Michaud Kaleb, Lee Yvonne C
Rush University Medical Center, Chicago, IL, USA.
Chicago Center on Musculoskeletal Pain, Chicago, IL, USA.
Arthritis Care Res (Hoboken). 2025 May 12. doi: 10.1002/acr.25571.
Pain is an often overlooked and understudied symptom in inflammatory myopathies (IIM). In this study, our goal is to examine the prevalence of pain and factors associated with pain in adults with IIM.
FORWARD is a US-based prospective registry of adults with rheumatic diseases recruited from rheumatology clinics. Participants had physician diagnosis of IIM and completed questionnaires on pain, fatigue, physical function, disease activity, and sociodemographic variables. Pain prevalence was examined in demographic and disease subgroups. Regression models were performed to identify any factors associated with higher levels of pain (>3 pain on visual analog scale). The relationship between pain and outcome variables was examined through Pearson correlations, t-test and chi-square test.
A total of 189 IIM patients (age 55 years ± 14, 78% women) from FORWARD Databank were included in the study. Approximately 86% reported pain with an average of 3.5 on a 10-point visual analog scale. One in four patients were on opioids. Approximately 62-63% reported joint and muscle pain, respectively. Pain prevalence was similar across subgroups of disease subtype, sex, race, smoking, and obesity. Patient global disease activity was significantly associated with higher pain levels in multivariable models. Pain was significantly associated with worse physical function, fatigue, quality of life and health satisfaction.
Pain is prevalent and associated with poor outcomes in patients with IIM. Pain is closely linked with patient global disease activity. Results highlight the critical need to better understand the pain experienced by these patients to best address their needs.
疼痛是炎性肌病（IIM）中一种常被忽视且研究不足的症状。在本研究中，我们的目标是调查IIM成年患者中疼痛的患病率以及与疼痛相关的因素。
FORWARD是一项基于美国的前瞻性登记研究，研究对象是从风湿病诊所招募的成年风湿病患者。参与者经医生诊断为IIM，并完成了关于疼痛、疲劳、身体功能、疾病活动度和社会人口统计学变量的问卷调查。在人口统计学和疾病亚组中检查疼痛患病率。进行回归模型分析以确定与较高疼痛水平（视觉模拟量表评分>3分）相关的任何因素。通过Pearson相关性分析、t检验和卡方检验研究疼痛与结局变量之间的关系。
本研究纳入了来自FORWARD数据库的189例IIM患者（年龄55岁±14岁，78%为女性）。约86%的患者报告有疼痛，在10分视觉模拟量表上的平均评分为3.5分。四分之一的患者正在使用阿片类药物。分别约62%和63%的患者报告有关节痛和肌肉痛。疾病亚型、性别、种族、吸烟和肥胖等亚组中的疼痛患病率相似。在多变量模型中，患者整体疾病活动度与较高的疼痛水平显著相关。疼痛与较差的身体功能、疲劳、生活质量和健康满意度显著相关。
疼痛在IIM患者中普遍存在且与不良结局相关。疼痛与患者整体疾病活动度密切相关。研究结果凸显了更好地了解这些患者所经历的疼痛以最佳满足其需求的迫切必要性。
