Ren Wenwen, Liu Conghui, Yan Ying, Han Ming, Xiang Pan, Pang Qi, Zhang Aihua
Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, People's Republic of China.
Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, People's Republic of China.
Int J Nephrol Renovasc Dis. 2025 May 8;18:123-132. doi: 10.2147/IJNRD.S511844. eCollection 2025.
Mitsugumin 53 (MG53) plays a protective role against kidney diseases and cardiovascular diseases, but its mechanism of action is unclear. We speculate that the prevention of cardiovascular disease by MG53 may be associated with the inhibition of vascular calcification. This study was performed with the aim of investigating the potential association between the MG53 level and abdominal aortic calcification (AAC) in patients undergoing hemodialysis (HD).
A total of 263 patients undergoing HD and 65 age- and sex-matched healthy individuals were included. The patient serum MG53 level was measured by enzyme-linked immunosorbent assay (ELISA), and the abdominal aortic calcification score (ACCs) was calculated using lateral abdominal radiography parameters. The laboratory and demographic data were collected at baseline.
The erum MG53 levels in HD patients were significantly lower than those in healthy individuals [24.9 (IQR: 16.1-40.1) vs 43.5 (IQR: 23.7-74.4) pg/mL, P < 0.001]. In addition, HD patients with AAC presented markedly lower serum MG53 levels than those without AAC [22.0 (IQR: 15.3-32.6) vs 26.9 (IQR: 16.8-44.2) pg/mL, p=0.024]. Furthermore, multiple logistic regression analysis indicated that lower serum MG53 levels, an older age, a longer dialysis vintage, a higher serum total carbon dioxide (TCO), and a higher serum phosphorus were independent risk factors for AAC in HD patients.
Our results demonstrate for the first time a correlation between lower serum MG53 levels and an increased risk of AAC in patients undergoing HD. In addition, an older age, a longer dialysis vintage, the presence of metabolic acidosis and higher serum phosphorus levels are independent risk factors for AAC in HD patients.
三宅素53（MG53）对肾脏疾病和心血管疾病具有保护作用，但其作用机制尚不清楚。我们推测MG53对心血管疾病的预防作用可能与抑制血管钙化有关。本研究旨在调查血液透析（HD）患者中MG53水平与腹主动脉钙化（AAC）之间的潜在关联。
共纳入263例接受HD治疗的患者和65例年龄及性别匹配的健康个体。采用酶联免疫吸附测定（ELISA）法检测患者血清MG53水平，并利用腹部侧位X线摄影参数计算腹主动脉钙化评分（ACCs）。在基线时收集实验室和人口统计学数据。
HD患者的血清MG53水平显著低于健康个体[24.9（四分位间距：16.1 - 40.1）对43.5（四分位间距：23.7 - 74.4）pg/mL，P < 0.001]。此外，患有AAC的HD患者血清MG53水平明显低于未患AAC的患者[22.0（四分位间距：15.3 - 32.6）对26.9（四分位间距：
