Jiang Zeyi, Lhamo Gamar, Ma Mengjie, Ye Xuxia, Chen Jin, He Yibo, Xu Jian, Huang Liquan
The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China.
School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Front Pharmacol. 2025 Apr 28;16:1587314. doi: 10.3389/fphar.2025.1587314. eCollection 2025.
Acute pancreatitis (AP) is a severe inflammatory disorder of the pancreas, characterized by high morbidity and mortality rates. Despite significant advancements in understanding the pathophysiological mechanisms of AP, current treatment options still face considerable limitations. Recent studies have underscored the therapeutic potential of quercetin, a natural flavonoid, due to its potent antioxidant, anti-inflammatory, and immunomodulatory properties, positioning it as a promising therapeutic candidate for AP. This review explores the effects of quercetin on AP, highlighting its antioxidant activities, its role in immune modulation, and its protective effects on pancreatic tissue. Furthermore, it examines quercetin's multi-target mechanisms and its advantages over conventional therapies, such as N-acetylcysteine and corticosteroids. Although preliminary studies suggest that quercetin can alleviate inflammation and oxidative stress in AP, clinical evidence remains limited. One of the main challenges for quercetin's clinical application is its low bioavailability. Future research should focus on strategies to enhance its bioavailability and on conducting large-scale randomized controlled trials to more comprehensively assess its efficacy and safety in the treatment of AP.
急性胰腺炎（AP）是一种严重的胰腺炎症性疾病，其特征是发病率和死亡率较高。尽管在理解AP的病理生理机制方面取得了重大进展，但目前的治疗选择仍然面临相当大的局限性。最近的研究强调了槲皮素（一种天然黄酮类化合物）的治疗潜力，因其具有强大的抗氧化、抗炎和免疫调节特性，使其成为AP有前景的治疗候选药物。本综述探讨了槲皮素对AP的影响，突出了其抗氧化活性、在免疫调节中的作用以及对胰腺组织的保护作用。此外，还研究了槲皮素的多靶点机制及其相对于传统疗法（如N-乙酰半胱氨酸和皮质类固醇）的优势。尽管初步研究表明槲皮素可以减轻AP中的炎症和氧化应激，但临床证据仍然有限。槲皮素临床应用的主要挑战之一是其低生物利用度。未来的研究应侧重于提高其生物利用度的策略，并进行大规模随机对照试验，以更全面地评估其在治疗AP中的疗效和安全性。
