González-Alcorta Celia B, Alcorta-Garza Adelina, Ruiz-Sánchez Daneli, Soto-Martínez Blanca Angélica, Alcorta-Núñez Fernando, Galaviz-Reynoso Itzel Lidey, López-Sierra Paola A, González-Guerrero Juan Francisco, Vidal-Gutiérrez Oscar
Oncology Service, Area of Radiooncology, University Center Against Cancer, University Hospital "José E. González", Universidad Autónoma de Nuevo León, Monterrey, Mexico.
Coordination of Psycho-Oncology and Liaison between Medicine and Palliative Care, University Center Against Cancer, University Hospital "José E. González", Universidad Autónoma de Nuevo León, Monterrey, Mexico.
Front Med (Lausanne). 2025 Apr 28;12:1584141. doi: 10.3389/fmed.2025.1584141. eCollection 2025.
Research on low-dose-rate (LDR) brachytherapy for gynecological cancer primarily examines treatment toxicity while overlooking aspects such as sexual desire, arousal, orgasm, satisfaction, and overall quality of life. We assessed sexual function and quality of life in patients with cervical and endometrial cancer before and after LDR brachytherapy, identifying factors related to sexual dysfunction and good quality of life 3-6 months after brachytherapy.
We prospectively followed a cohort of patients with a histopathological diagnosis of cervical and endometrial cancer who were treated with LDR intracavitary brachytherapy ( = 139). The SyDSF-AP, FACT-G, PHQ-9, and PHQ-15 scales were collected using a self-administered questionnaire before and 3-6 months after treatment. The analysis included estimating incidence rates and conducting a binary multiple logistic regression.
Sexual dysfunction was observed in 14.4% of individuals, with 30% already affected at baseline. Higher education was associated with a decreased likelihood of developing or maintaining sexual dysfunction (OR, 0.10; 95% CI, 0.01-0.97). Physical wellbeing improved after treatment, with scores increasing from 69.3 to 78.7 ( < 0.001; effect size = 0.34). The presence of moderate-to-severe somatic symptoms, major depression, and sexual dysfunction reduced the likelihood of starting or maintaining a good quality of life.
Over 10% of patients experienced sexual dysfunction, with physical wellbeing being the only area that showed improvement after treatment. Research in this area enhances awareness and understanding of how healthcare providers can better support sexual and health-related wellbeing.
关于妇科癌症低剂量率（LDR）近距离放射治疗的研究主要关注治疗毒性，而忽视了性欲、性唤起、性高潮、满意度和总体生活质量等方面。我们评估了宫颈癌和子宫内膜癌患者在LDR近距离放射治疗前后的性功能和生活质量，确定了与近距离放射治疗后3至6个月性功能障碍和良好生活质量相关的因素。
我们前瞻性地跟踪了一组经组织病理学诊断为宫颈癌和子宫内膜癌并接受LDR腔内近距离放射治疗的患者（ = 139）。在治疗前和治疗后3至6个月，通过自填问卷收集SyDSF-AP、FACT-G、PHQ-9和PHQ-15量表。分析包括估计发病率并进行二元多因素逻辑回归。
14.4%的个体出现性功能障碍，30%在基线时就已受到影响。高等教育与发生或维持性功能障碍的可能性降低相关（比值比，0.10；95%置信区间，0.01-0.97）。治疗后身体健康状况有所改善，得分从69.3提高到78.7（ < 0.001；效应大小 = 0.34）。中度至重度躯体症状、重度抑郁症和性功能障碍的存在降低了开始或维持良好生活质量的可能性。
超过10%的患者出现性功能障碍，身体健康是治疗后唯一显示出改善的领域。该领域的研究提高了人们对医疗保健提供者如何更好地支持性健康和与健康相关的幸福感的认识和理解。
