Famuyiwa O O, Odia O J, Osotimehin B O, Adenle A D, Falase A O
Trop Geogr Med. 1985 Jun;37(2):143-9.
Non-invasive cardiac studies using systolic time intervals were performed on 89 diabetic Nigerians and 45 non-diabetic controls, to investigate possible preclinical abnormality of left ventricular function. There was no significant difference in the pre-ejection period to left ventricular ejection time ratio (PEP/LVET) between the patients and controls: 0.373 +/- 0.011 vs 0.365 +/- 0.013 (P = 0.688). Patients at higher risk for developing significant vascular disease i.e. those with peripheral vascular insufficiency, those in higher socio-economic class and those with disease duration of 10 or more years had the highest mean values of PEP/LVET (0.403, 0.403 and 0.412 respectively). However, these values did not reach a level of significance. There was no correlation between PEP/LVET and age, body mass index, duration of diabetes, total or HDL cholesterol and the HDL to total cholesterol ratio. Because recent reports have related diabetic cardiomyopathy to angiopathic disease in diabetes, these results suggest that Nigerian patients, who like most other black African diabetics show little susceptibility to severe vascular complications of diabetes may enjoy some protection from a preclinical abnormality of left ventricular function as well.
对89名尼日利亚糖尿病患者和45名非糖尿病对照者进行了使用收缩期时间间期的非侵入性心脏研究，以调查左心室功能可能存在的临床前异常。患者和对照者的射血前期与左心室射血时间比值（PEP/LVET）无显著差异：分别为0.373±0.011和0.365±0.013（P = 0.688）。发生严重血管疾病风险较高的患者，即那些患有外周血管功能不全的患者、社会经济阶层较高的患者以及病程达10年或更长时间的患者，其PEP/LVET的平均值最高（分别为0.403、0.403和0.412）。然而，这些值未达到显著水平。PEP/LVET与年龄、体重指数、糖尿病病程、总胆固醇或高密度脂蛋白胆固醇以及高密度脂蛋白与总胆固醇比值之间无相关性。由于最近的报告已将糖尿病性心肌病与糖尿病中的血管病变相关联，这些结果表明，与大多数其他非洲黑人糖尿病患者一样，对糖尿病严重血管并发症几乎没有易感性的尼日利亚患者，可能也能免受左心室功能临床前异常的影响。
