Kitaya Kotaro
Infertility Center, Iryouhoujin Kouseikai Mihara Hospital, 6-8 Kamikatsura Miyanogo-cho, Nishikyo-ku, Kyoto 615-8227, Japan.
Cells. 2025 Apr 29;14(9):648. doi: 10.3390/cells14090648.
Immunocompetent cells of B lineage function in the humoral immunity system in the adaptive immune responses. B cells differentiate into plasmacytes upon antigen-induced activation and produce different subclasses of immunoglobulins/antibodies. Secreted immunoglobulins not only interact with pathogens to inactivate and neutralize them, but also involve the complement system to exert antibacterial activities and trigger opsonization. Endometrium is a mucosal tissue that lines the mammalian uterus and is indispensable for the establishment of a successful pregnancy. The lymphocytes of B cell lineage are a minority in the human cycling endometrium. Human endometrial B cells have therefore been understudied so far. However, the disorders of the female reproductive tract, including chronic endometritis and endometriosis, have highlighted the importance of further research on the endometrial B cell lineage. This review aims to revisit lymphopoiesis, maturation, commitment, and survival of B cells, shedding light on their physiological and pathological implications in the human endometrium.
B淋巴细胞系的免疫活性细胞在适应性免疫反应的体液免疫系统中发挥作用。B细胞在抗原诱导激活后分化为浆细胞，并产生不同亚类的免疫球蛋白/抗体。分泌的免疫球蛋白不仅与病原体相互作用使其失活并中和，还参与补体系统发挥抗菌活性并触发调理作用。子宫内膜是衬于哺乳动物子宫的一种黏膜组织，对于成功怀孕不可或缺。B细胞系淋巴细胞在人类周期性子宫内膜中占少数。因此，到目前为止，人类子宫内膜B细胞一直未得到充分研究。然而，包括慢性子宫内膜炎和子宫内膜异位症在内的女性生殖道疾病凸显了进一步研究子宫内膜B细胞系的重要性。本综述旨在重新审视B细胞的淋巴细胞生成、成熟、定向和存活，阐明其在人类子宫内膜中的生理和病理意义。
