Université Paris Cité, Institut de Recherche Saint-Louis, INSERM U1160, Paris, France; OPALE Carnot Institute, The Organization for Partnerships in Leukemia, Hôpital Saint-Louis, Paris, France.
Université Paris Cité, Institut de Recherche Saint-Louis, INSERM U1160, Paris, France; OPALE Carnot Institute, The Organization for Partnerships in Leukemia, Hôpital Saint-Louis, Paris, France.
Curr Opin Immunol. 2024 Jun;88:102442. doi: 10.1016/j.coi.2024.102442. Epub 2024 Jul 3.
Plasma cells correspond to the last stage of B cell differentiation and are professional antibody-secreting cells. While most persist for only few days, some may survive for weeks to years in dedicated survival niches. The determination of plasma cell survival rate seems to rely both on intrinsic and extrinsic factors. Although often opposed, the deterministic and environmental models for plasma cell longevity are certainly overlapping. Understanding the contribution and the regulation of these different factors is paramount to develop better vaccines but also to target malignant plasma cells. Here, we review recent literature highlighting new findings pertaining to plasma cell survival rate, intrinsic regulation of plasma cell persistence and function, as well as the plasma cell/niche dialogue. Moreover, the now well-recognised heterogeneity observed among plasma cells is also discussed.
浆细胞对应于 B 细胞分化的最后阶段，是专业的抗体分泌细胞。虽然大多数浆细胞仅持续几天，但一些浆细胞可能在专门的生存龛中存活数周甚至数年。浆细胞存活率的决定似乎既依赖于内在因素，也依赖于外在因素。尽管这两种模型常常相互矛盾，但决定浆细胞寿命的确定性模型和环境模型肯定是重叠的。了解这些不同因素的贡献和调节对于开发更好的疫苗以及靶向恶性浆细胞至关重要。在这里，我们回顾了最近的文献，强调了与浆细胞存活率、浆细胞持久性和功能的内在调节以及浆细胞/龛对话相关的新发现。此外，还讨论了现在公认的浆细胞之间的异质性。
