Edvardsen Elisabeth, Ruud Ellen, Rueegg Corina Silvia, Kvidaland Haakon Kristian, Torsvik Ingrid Kristin, Bovim Lars Peder Vatshelle, Grydeland May, von der Weid Nicolas, Anderssen Sigmund Alfred, Kriemler Susi, Raastad Truls
Department of Physical Performance, Norwegian School of Sport Sciences, Oslo, NORWAY.
Department of Health and Functioning, Faculty of Health and Social Sciences, Western Norway University of Applied Sciences, Bergen, NORWAY.
Med Sci Sports Exerc. 2025 May 13. doi: 10.1249/MSS.0000000000003758.
To compare physical fitness, function and physical activity (PA) in adolescent childhood cancer survivors (CCSs) to age- and sex-matched controls and across different cancer diagnoses.
This multicenter cross-sectional study (PACCS) included CCSs aged 9-18 years (≥1-year after cancer treatment) and age- and sex-matched controls. Physical fitness tests included cardiorespiratory fitness (VO2max) and muscular strength (maximal isometric handgrip, knee-extension, and chest-press). Physical function tests included a 1-min sit-to-stand test (STS) and countermovement jump (CMJ). PA was measured by accelerometer for seven days. We used linear mixed effects models to compare outcomes between CCSs and controls, and across diagnostic groups.
We included 157 CCSs and 113 controls, aged 13.4 ± 2.6 years (mean ± SD). Cancer types were leukemia (n = 78), central nervous system (CNS) tumors (n = 18), lymphoma (n = 16), and other solid tumors (n = 45). CCSs had lower VO2max (marginal mean [95% confidence interval]) 41.7 [38.4-45.0] vs 46.4 [42.9-49.8] mL·kg-1·min-1, P < 0.001), knee-extension strength (35.4 [34.1-36.8] vs 38.2 [36.7-39.7] kg, P = 0.003), chest-press strength (30.0 [28.4-31.6] vs 32.8 [31.0-34.7] kg, P = 0.007), STS repetitions (57.5 [55.8-59.3] vs 60.0 [58.0-62.0] P = 0.017), and CMJ height (22.1, [20.5-23.8] vs 24.9 [23.2-26.6] cm, P < 0.001). PA levels and sedentary time were similar in both groups (8513 [7993-9034] vs 9000 [8404-9596] steps per day, P = 0.174, respectively). Survivors of CNS tumors had the lowest values for VO2max, muscular strength, physical function and PA.
Despite no significant difference in PA levels, adolescent CCSs had 4.2% to 11% lower physical fitness and function compared to controls, where survivors of CNS tumors performed poorest.
比较青少年期癌症幸存者（CCSs）与年龄和性别匹配的对照组在身体素质、功能和身体活动（PA）方面的差异，并比较不同癌症诊断类型的情况。
这项多中心横断面研究（PACCS）纳入了9至18岁（癌症治疗后≥1年）的CCSs以及年龄和性别匹配的对照组。身体素质测试包括心肺适能（最大摄氧量）和肌肉力量（最大等长握力、伸膝力量和卧推力量）。身体功能测试包括1分钟坐立试验（STS）和反向纵跳（CMJ）。通过加速度计测量PA，为期7天。我们使用线性混合效应模型比较CCSs与对照组之间以及不同诊断组之间的结果。
我们纳入了157名CCSs和113名对照组，年龄为13.4±2.6岁（平均值±标准差）。癌症类型包括白血病（n = 78）、中枢神经系统（CNS）肿瘤（n = 18）、淋巴瘤（n = 16）和其他实体瘤（n = 45）。CCSs的最大摄氧量较低（边际均值[95%置信区间]），分别为41.7[38.4 - 45.0]与46.4[42.9 - 49.8]mL·kg⁻¹·min⁻¹，P < 0.001），伸膝力量（35.4[34.1 - 36.8]与38.2[36.7 - 39.7]kg，P = 0.003），卧推力量（30.0[28.4 - 31.6]与32.8[31.0 - 34.7]kg，P = 0.007），STS重复次数（57.5[55.8 - 59.3]与60.0[58.0 - 62.0]，P = 0.017），以及CMJ高度（22.1，[20.5 - 23.8]与24.9[23.2 - 26.6]cm，P < 0.001）。两组的PA水平和久坐时间相似（分别为每天8513[7993 - 9034]与9000[8404 - 9596]步，P = 0.174）。CNS肿瘤幸存者的最大摄氧量、肌肉力量、身体功能和PA值最低。
尽管PA水平无显著差异，但与对照组相比，青少年CCSs的身体素质和功能低4.2%至11%，其中CNS肿瘤幸存者表现最差。
