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广泛获得的抗菌耐药菌会在抗生素使用后的条件下重塑个体微生物群落。

Extensively acquired antimicrobial-resistant bacteria restructure the individual microbial community in post-antibiotic conditions.

作者信息

Baek Jae Woo, Lim Songwon, Park Nayeon, Song Byeongsop, Kirtipal Nikhil, Nielsen Jens, Mardinoglu Adil, Shoaie Saeed, Kim Jae-Il, Son Jang Won, Koh Ara, Lee Sunjae

机构信息

Department of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.

Department of Biology and Biological Engineering, Kemivägen 10, Chalmers University of Technology, Gothenburg, Sweden.

出版信息

NPJ Biofilms Microbiomes. 2025 May 14;11(1):78. doi: 10.1038/s41522-025-00705-x.

DOI:10.1038/s41522-025-00705-x
PMID:40360555
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12075632/
Abstract

In recent years, the overuse of antibiotics has led to the emergence of antimicrobial-resistant (AMR) bacteria. To evaluate the spread of AMR bacteria, the reservoir of AMR genes (resistome) has been identified in environmental samples, hospital environments, and human populations, but the functional role of AMR bacteria and their persistence within individuals has not been fully investigated. Here, we performed a strain-resolved in-depth analysis of the resistome changes by reconstructing a large number of metagenome-assembled genomes from the gut microbiome of an antibiotic-treated individual. Interestingly, we identified two bacterial populations with different resistome profiles: extensively acquired antimicrobial-resistant bacteria (EARB) and sporadically acquired antimicrobial-resistant bacteria, and found that EARB showed broader drug resistance and a significant functional role in shaping individual microbiome composition after antibiotic treatment. Our findings of AMR bacteria would provide a new avenue for controlling the spread of AMR bacteria in the human community.

摘要

近年来，抗生素的过度使用导致了抗菌药物耐药（AMR）细菌的出现。为了评估AMR细菌的传播情况，人们已经在环境样本、医院环境和人群中鉴定出了AMR基因库（耐药基因组），但AMR细菌的功能作用及其在个体内的持续性尚未得到充分研究。在此，我们通过从一名接受抗生素治疗个体的肠道微生物组中重建大量宏基因组组装基因组，对耐药基因组的变化进行了菌株解析的深入分析。有趣的是，我们鉴定出了两个具有不同耐药基因组特征的细菌群体：广泛获得性抗菌药物耐药细菌（EARB）和偶发性获得性抗菌药物耐药细菌，并发现EARB显示出更广泛的耐药性，且在抗生素治疗后对塑造个体微生物组组成具有重要的功能作用。我们关于AMR细菌的研究结果将为控制AMR细菌在人类群体中的传播提供一条新途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb0/12075632/6456a3765ef1/41522_2025_705_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb0/12075632/c9c38a564a12/41522_2025_705_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb0/12075632/4587ac9c21d6/41522_2025_705_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb0/12075632/b70857964565/41522_2025_705_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb0/12075632/7a8b9520ce16/41522_2025_705_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb0/12075632/6fae765174f6/41522_2025_705_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb0/12075632/6456a3765ef1/41522_2025_705_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb0/12075632/c9c38a564a12/41522_2025_705_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb0/12075632/4587ac9c21d6/41522_2025_705_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb0/12075632/b70857964565/41522_2025_705_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb0/12075632/7a8b9520ce16/41522_2025_705_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb0/12075632/6fae765174f6/41522_2025_705_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb0/12075632/6456a3765ef1/41522_2025_705_Fig6_HTML.jpg

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本文引用的文献

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Impact of COVID-19 pandemic on multidrug resistant gram positive and gram negative pathogens: A systematic review.新冠疫情对耐多药革兰阳性和革兰阴性病原体的影响：系统综述。
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Colicins and Microcins Produced by : Characterization, Mode of Action, and Putative Applications.
由 产生的肠毒素和微菌素：特性、作用模式和潜在应用。
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Overabundance of Veillonella parvula promotes intestinal inflammation by activating macrophages via LPS-TLR4 pathway.小韦荣球菌过量通过脂多糖- toll样受体4途径激活巨噬细胞，促进肠道炎症。
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