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利用高剂量和超高剂量率单脉冲质子源的激光驱动FLASH放射生物学。

Laser driven FLASH radiobiology using a high dose and ultra high dose rate single pulse proton source.

作者信息

Flacco A, Bayart E, Romagnani L, Cavallone M, De Marzi L, Fouillade C, Giaccaglia C, Heinrich S, Lamarre-Jouenne I, Monzac J, Parodi K, Patriarca A, Rösch T, Schreiber J, Tischendorf L

机构信息

Laboratoire d'Optique Appliquée, ENSTA Paris, CNRS, Ecole Polytechnique, Institut Polytechnique de Paris, 91120, Palaiseau, France.

LULI, CNRS, École Polytechnique, Institut Polytechnique de Paris, 91120, Palaiseau, France.

出版信息

Sci Rep. 2025 May 13;15(1):16511. doi: 10.1038/s41598-025-01105-z.

DOI:10.1038/s41598-025-01105-z
PMID:40360597
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12075504/
Abstract

Laser-driven proton sources have long been developed with an eye on their potential for medical application to radiation therapy. These sources are compact, versatile, and show peculiar characteristics such as extreme instantaneous dose rates, short duration and broad energy spectrum. Typical temporal modality of laser-driven irradiation, the so-called fast-fractionation, results from the composition of multiple, temporally separated, ultra-short dose fractions. In this paper we present the use of a high-energy laser system for delivering the target dose in a single nanosecond pulse, for ultra-fast irradiation of biological samples. A transport line composed by two permanent-magnet quadrupoles and a scattering system is used to improve the dose profile and to control the delivered dose-per-pulse. A single-shot dosimetry protocol for the broad-spectrum proton source using Monte Carlo simulations was developed. Doses as high as 20 Gy could be delivered in a single shot, lasting less than 10 ns over a 1 cm diameter biological sample, at a dose-rate exceeding [Formula: see text]. Exploratory application of extreme laser-driven irradiation conditions, falling within the FLASH irradiation protocol, are presented for irradiation in vitro and in vivo. A reduction of radiation-induced oxidative stress in vitro and radiation-induced developmental damage compatible with the onset of FLASH effect were observed in vivo, whereas anti-tumoral efficacy was confirmed by cell survival assay.

摘要

长期以来，人们一直在研发激光驱动质子源，着眼于其在放射治疗医学应用方面的潜力。这些源紧凑、通用，并展现出诸如极高的瞬时剂量率、短持续时间和宽能谱等独特特性。激光驱动照射的典型时间模式，即所谓的快速分次照射，是由多个时间上分离的超短剂量分次组成的。在本文中，我们展示了使用高能激光系统在单个纳秒脉冲中输送目标剂量，用于对生物样品进行超快照射。由两个永磁四极杆和一个散射系统组成的传输线用于改善剂量分布并控制每脉冲输送的剂量。开发了一种使用蒙特卡罗模拟的广谱质子源单脉冲剂量测定方案。在直径为1厘米的生物样品上，单次照射可在不到10纳秒的时间内输送高达20 Gy的剂量，剂量率超过[公式：见原文]。本文介绍了在体外和体内照射中应用属于FLASH照射方案的极端激光驱动照射条件的探索性研究。在体外观察到辐射诱导的氧化应激减少，在体内观察到与FLASH效应开始相符的辐射诱导发育损伤减少，而通过细胞存活试验证实了抗肿瘤功效。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e323/12075504/39f62d7e2ab7/41598_2025_1105_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e323/12075504/d2d9e82c723b/41598_2025_1105_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e323/12075504/d4db3c25eea2/41598_2025_1105_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e323/12075504/98f61a1cecd4/41598_2025_1105_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e323/12075504/8bd5b81b00b2/41598_2025_1105_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e323/12075504/a3ba53a87468/41598_2025_1105_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e323/12075504/444bef07f5d5/41598_2025_1105_Fig13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e323/12075504/0be7b83ff27b/41598_2025_1105_Fig14_HTML.jpg
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本文引用的文献

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Phys Rev E. 2024 Sep;110(3-2):035204. doi: 10.1103/PhysRevE.110.035204.
2
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Phys Med Biol. 2023 Jan 9;68(2). doi: 10.1088/1361-6560/aca387.
3
Towards clinical translation of FLASH radiotherapy.迈向 FLASH 放疗的临床转化。
Nat Rev Clin Oncol. 2022 Dec;19(12):791-803. doi: 10.1038/s41571-022-00697-z. Epub 2022 Oct 27.
4
Comparing radiolytic production of HO and development of Zebrafish embryos after ultra high dose rate exposure with electron and transmission proton beams.比较超高剂量率电子束和传输质子束辐照后 HO 的放射分解产物和斑马鱼胚胎的发育。
Radiother Oncol. 2022 Oct;175:197-202. doi: 10.1016/j.radonc.2022.07.011. Epub 2022 Jul 19.
5
A new platform for ultra-high dose rate radiobiological research using the BELLA PW laser proton beamline.一种使用 BELLA PW 激光质子束线进行超高剂量率放射生物学研究的新平台。
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6
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Anticancer Res. 2020 Nov;40(11):6123-6135. doi: 10.21873/anticanres.14633.
7
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