Usman Abdullahi G, Mati Sagiru, Daud Hanita, Suleiman Ahmad Abubakar, Abba Sani I, Ahmad Hijaz, Radwan Taha
Department of Analytical Chemistry, Faculty of Pharmacy, Near East University, 99138, Nicosia, Turkish Republic of Northern Cyprus.
Operational Research Centre in Healthcare, Near East University, Nicosia, Turkish Republic of Northern Cyprus.
Sci Rep. 2025 May 13;15(1):16569. doi: 10.1038/s41598-025-99908-7.
The accurate determination of mycotoxins in food samples is crucial to guarantee food safety and minimize their toxic effects on human and animal health. This study proposed the use of a support vector regression (SVR) predictive model improved by two metaheuristic algorithms used for optimization namely, Harris Hawks Optimization (HHO) and Particle Swarm Optimization (PSO) to predict chromatographic retention time of various food mycotoxin groups. The dataset was collected from secondary sources and used to train and validate the SVR-HHO and SVR-PSO models. The performance of the models was assessed via mean square error, correlation coefficient, and Nash-Sutcliffe efficiency. The SVR-HHO model outperformed existing methods by 4-7% in both the two learning (training and testing) phases respectively. By using metaheuristic optimization, parameter adjustment became more effective, avoiding trapping in local minima and improving model generalization. These results demonstrate how machine learning and metaheuristics may be combined to accurately forecast mycotoxin levels, providing a useful tool for regulatory compliance and food safety monitoring. The SVR-HHO framework is perfect for commercial quality assurance, regulatory testing, and extensive food safety programs because it provides exceptional accuracy and resilience in predicting mycotoxin retention times. In contrast to conventional models, SVR-HHO effectively manages intricate nonlinear interactions, guaranteeing accurate mycotoxin identification and improving food safety while lowering hazards to human and animal health.
准确测定食品样品中的霉菌毒素对于保障食品安全以及将其对人类和动物健康的毒性影响降至最低至关重要。本研究提出使用一种支持向量回归(SVR)预测模型,该模型通过两种用于优化的元启发式算法进行改进,即哈里斯鹰优化算法(HHO)和粒子群优化算法(PSO),以预测各类食品霉菌毒素组的色谱保留时间。数据集从二手来源收集,并用于训练和验证SVR - HHO和SVR - PSO模型。通过均方误差、相关系数和纳什 - 萨特克利夫效率来评估模型的性能。SVR - HHO模型在两个学习阶段(训练和测试)分别比现有方法性能高出4 - 7%。通过使用元启发式优化,参数调整变得更加有效,避免陷入局部最小值并提高了模型的泛化能力。这些结果表明了如何将机器学习和元启发式方法相结合以准确预测霉菌毒素水平,为监管合规和食品安全监测提供了一个有用的工具。SVR - HHO框架非常适合商业质量保证、监管测试和广泛的食品安全计划,因为它在预测霉菌毒素保留时间方面具有出色的准确性和稳健性。与传统模型相比,SVR - HHO有效地处理复杂的非线性相互作用,确保准确识别霉菌毒素,在降低对人类和动物健康危害的同时提高食品安全。