Lussana Francesca, Lanzarone Ettore, Villa Giulia, Mastropietro Alfonso, Caroli Anna, Scalco Elisa
Department of Management, Information and Production Engineering, University of Bergamo, 24044, Dalmine, BG, Italy.
Bioengineering Department, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 24020, Ranica, BG, Italy.
Sci Rep. 2025 May 13;15(1):16526. doi: 10.1038/s41598-025-99982-x.
Autosomal dominant polycystic kidney disease (ADPKD) is a prevalent hereditary disorder characterized by the development and growth of fluid-filled cysts, resulting in a decline in kidney function. Beyond total kidney and cyst volume quantification, non-cystic tissue characterization by multi-parametric MRI (mp-MRI) and radiomics holds promise. We conducted a radiomic analysis based on reproducible and informative features extracted from non-cystic tissue on mp-MRI in ADPKD patients. T2-weighted (T2-w), T1-weighted MRI (T1-w), and IntraVoxel Incoherent Motion (IVIM) maps from Diffusion Weighted Imaging (DWI) were considered. The reliability of radiomic features was evaluated using five different segmentation methods. The impact of segmentation variability on radiomic reproducibility was assessed through Intraclass Correlation Coefficients (ICC), and a preliminary correlation analysis with relevant clinical parameters, such as age and eGFR, was also performed. The results from 14 patients indicate that radiomic features derived from IVIM maps exhibit greater reliability compared to features from T1-w and T2-w for characterizing non-cystic tissue in ADPKD patients, also showing a moderate correlation with age and eGFR. Additionally, lower-order features, including those computed from histograms and co-occurrence matrices, demonstrate higher reproducibility than other texture features.
常染色体显性多囊肾病（ADPKD）是一种常见的遗传性疾病，其特征是充满液体的囊肿的形成和生长，导致肾功能下降。除了对整个肾脏和囊肿体积进行量化外，通过多参数磁共振成像（mp-MRI）和影像组学对非囊肿组织进行特征描述也具有前景。我们基于从ADPKD患者mp-MRI的非囊肿组织中提取的可重复且信息丰富的特征进行了影像组学分析。考虑了来自扩散加权成像（DWI）的T2加权（T2-w）、T1加权磁共振成像（T1-w）和体素内不相干运动（IVIM）图。使用五种不同的分割方法评估影像组学特征的可靠性。通过组内相关系数（ICC）评估分割变异性对影像组学可重复性的影响，并对年龄和估算肾小球滤过率（eGFR）等相关临床参数进行了初步相关性分析。14名患者的结果表明，与T1-w和T2-w的特征相比，从IVIM图得出的影像组学特征在表征ADPKD患者的非囊肿组织方面表现出更高的可靠性，并且与年龄和eGFR也存在中度相关性。此外，包括从直方图和共生矩阵计算得出的低阶特征，比其他纹理特征具有更高的可重复性。
