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暴露于铅环境中的幼年猴子的暗视觉缺陷。

Scotopic vision deficits in young monkeys exposed to lead.

作者信息

Bushnell P J, Bowman R E, Allen J R, Marlar R J

出版信息

Science. 1977 Apr 15;196(4287):333-5. doi: 10.1126/science.403610.

Abstract

Rhesus monkeys were reared on diets designed to produce blood lead concentrations of 14 (untreated), 55, or 85 micrograms per 100 milliliters for the first year of life. Eighteen months later, blood lead levels were normal in all animals. At this time, however, visual discrimination performance in the 85-microgram group was impaired under dim light relative both to their own performance under bright light and to the performance of the other groups under all light levels used. We interpret these results to reflect a deleterious, enduring impairment of scotopic visual function (night blindness) as a result of early lead intoxication.

摘要

恒河猴在出生后的第一年食用特定饮食,以使血液铅浓度分别达到14(未处理组)、55或85微克/100毫升。18个月后,所有动物的血铅水平均恢复正常。然而,此时,85微克组在暗光下的视觉辨别能力相对于其在强光下的自身表现以及其他组在所有光照水平下的表现均受损。我们将这些结果解释为早期铅中毒导致的暗视觉功能(夜盲)的有害且持久的损伤。

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