Ding Jing, Xiao Yihan, Fu Jie, Huang Qionghui, Ma Zijun, Zhang Chao, Wang Yan, Liu Guoli, Wu Hongkun, Yuan Yifang
Department of Pediatrics, Peking University People's Hospital, Beijing, 100044, People's Republic of China.
Department of Gynecology and Obstetrics, Peking University People's Hospital, Beijing, 100044, People's Republic of China.
BMC Pediatr. 2025 May 13;25(1):376. doi: 10.1186/s12887-025-05744-z.
Preeclampsia is linked to fetal growth restriction and may have long-term implications for the offspring. Despite its significance, the fundamental mechanisms remain inadequately elucidated. The objective of this investigation was to undertake an untargeted lipidomics analysis of umbilical cord plasma, with the intention of investigating lipidomic profile alterations in newborns of mothers with preeclampsia and evaluating the associations between lipidomic patterns and neonatal physical parameters at birth.
25 newborns from mothers with preeclampsia (PE group) and 25 newborns from healthy mothers (control group) were involved in the present investigation. Untargeted lipidomics was performed using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to contrast the lipid compositions present in umbilical cord plasma. Co-expression correlation analysis was performed to explore the relationships between lipidomic patterns and neonatal weight and length percentile at birth.
Marked discrepancies in lipid metabolism profiles were detected in the comparison of the PE and control groups. In total, 364 separate lipids were noted, with AcylGlcADG (20:3-22:6-22:6) and GM3(d39:1) exhibiting the most significant decreases. Conversely, Cer-NS (d20:1-24:0) and DGTS (2:0-19:0) displayed the most significant increases. The primary lipid metabolic pathways altered in newborns from mothers with preeclampsia were enriched in choline and glycerophospholipid metabolic processes. Additionally, 20 distinct lipids exhibited significant associations with neonatal birth weight percentile between the two groups, while 21 distinct lipids showed significant associations with neonatal birth length percentile.
Lipid profile disorders were identified in the umbilical cord plasma of infants born to mothers with preeclampsia, and the metabolic disturbances identified in this group correlated with neonatal physical parameters at birth. These findings suggest that lipidomic disorders in newborns from preeclamptic mothers may correlate with intrauterine growth outcomes.
子痫前期与胎儿生长受限有关，可能对后代产生长期影响。尽管其意义重大，但其基本机制仍未得到充分阐明。本研究的目的是对脐带血血浆进行非靶向脂质组学分析，以研究子痫前期母亲所生新生儿的脂质组学特征变化，并评估脂质组学模式与出生时新生儿身体参数之间的关联。
本研究纳入了25名子痫前期母亲所生的新生儿（PE组）和25名健康母亲所生的新生儿（对照组）。使用超高效液相色谱-串联质谱（UPLC-MS/MS）进行非靶向脂质组学分析，以对比脐带血血浆中的脂质成分。进行共表达相关性分析，以探讨脂质组学模式与出生时新生儿体重和身长百分位数之间的关系。
在PE组和对照组的比较中，检测到脂质代谢谱存在明显差异。总共记录了364种不同的脂质，其中酰基葡萄糖甘油二酯（20:3-22:6-22:6）和神经节苷脂GM3（d39:1）下降最为显著。相反，神经酰胺NS（d20:1-24:0）和二酰基甘油磷酰胆碱（2:0-19:0）上升最为显著。子痫前期母亲所生新生儿中改变的主要脂质代谢途径在胆碱和甘油磷脂代谢过程中富集。此外，两组之间有20种不同的脂质与新生儿出生体重百分位数有显著关联，21种不同的脂质与新生儿出生身长百分位数有显著关联。
子痫前期母亲所生婴儿的脐带血血浆中存在脂质谱紊乱，该组中发现的代谢紊乱与出生时的新生儿身体参数相关。这些发现表明，子痫前期母亲所生新生儿的脂质组学紊乱可能与宫内生长结局相关。
