Karavasiloglou Nena, Thompson Alysha S, Pestoni Giulia, Suter Flurina, Papier Keren, Cassidy Aedín, Kühn Tilman, Rohrmann Sabine
Division of Chronic Disease Epidemiology, Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich, Zurich, Switzerland.
Cancer Registry of the cantons of Zurich, Zug, Schaffhausen, and Schwyz, University Hospital Zurich, Zurich, Switzerland.
BMC Med. 2025 May 13;23(1):286. doi: 10.1186/s12916-025-04106-x.
Significant advancements in treatment and care, as well as early detection, have contributed to an increase in cancer survival rates. Recently, the EAT-Lancet Commission on Food, Planet, Health proposed the "planetary health diet" but to date, no study has investigated the potential associations between adherence to the EAT-Lancet reference diet and mortality in cancer survivors. To determine whether higher adherence to the EAT-Lancet reference diet is associated with lower risk for all-cause, cancer, and cardiovascular mortality in cancer survivors.
Data from the prospective UK Biobank study were used. Information from UK Biobank's Touchscreen questionnaire was used to develop a score reflecting adherence to the EAT-Lancet reference diet. Cox proportional hazards regression was used to assess the association of the EAT-Lancet reference diet score with all-cause, cancer, and cardiovascular mortality in cancer survivors.
Within 25,348 cancer survivors, better adherence to the EAT-Lancet reference diet was inversely related to all-cause mortality (hazard ratio (HR): 0.97, 95% confidence interval (CI): 0.95-0.99), 1 unit increase) and cancer mortality (HR: 0.98, 95% CI: 0.96-1.00), while mostly null associations were observed for major cardiovascular mortality (HR: 0.99, 95% CI: 0.95-1.03).
Our findings suggest the adoption of the EAT-Lancet reference diet is associated with lower all-cause and cancer-specific mortality among cancer survivors.
治疗与护理方面的重大进展以及早期检测，促使癌症存活率有所提高。最近，《柳叶刀》食物、星球、健康委员会提出了“地球健康饮食”，但迄今为止，尚无研究调查遵循《柳叶刀》参考饮食与癌症幸存者死亡率之间的潜在关联。为了确定更高程度地遵循《柳叶刀》参考饮食是否与癌症幸存者全因、癌症和心血管疾病死亡率的较低风险相关。
使用了来自英国生物银行前瞻性研究的数据。利用英国生物银行触摸屏问卷中的信息来制定一个反映对《柳叶刀》参考饮食遵循程度的分数。采用Cox比例风险回归来评估《柳叶刀》参考饮食分数与癌症幸存者全因、癌症和心血管疾病死亡率之间的关联。
在25348名癌症幸存者中，更好地遵循《柳叶刀》参考饮食与全因死亡率（风险比（HR）：0.97，95%置信区间（CI）：0.95 - 0.99，每增加1个单位）和癌症死亡率（HR：0.98，95% CI：0.96 - 1.00）呈负相关，而对于主要心血管疾病死亡率大多观察到无关联（HR：0.99，95% CI：0.95 - 1.03）。
我们的研究结果表明，采用《柳叶刀》参考饮食与癌症幸存者较低的全因死亡率和癌症特异性死亡率相关。
