Ciubotaru Alin, Smihor Mădălina Irina, Grosu Cristina, Alexa Daniel, Covali Roxana, Anicăi Robert-Constantin, Păvăleanu Ioana, Cucu Andrei Ionuț, Bobu Amelian Mădălin, Ghiciuc Cristina Mihaela, Ignat Emilian Bogdan
Department of Neurology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Grigore T. Popa, University of Medicine and Pharmacy, 700115 Iasi, Romania.
Diagnostics (Basel). 2025 May 6;15(9):1178. doi: 10.3390/diagnostics15091178.
Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurodegeneration within the central nervous system (CNS). While the inflammatory components of MS have been extensively studied, the progressive neurodegenerative aspect remains a critical factor contributing to long-term disability. Therefore, the identification and validation of biomarkers associated with neurodegenerative processes are essential for improved diagnosis, prognosis, and treatment monitoring. This review explores cerebrospinal fluid (CSF) and blood-based biomarkers, including neurofilaments, lipid markers, kynurenines, and other molecular indicators that provide insights into neurodegeneration in MS.
多发性硬化症（MS）是一种慢性自身免疫性疾病，其特征是中枢神经系统（CNS）内发生炎症、脱髓鞘和神经退行性变。虽然MS的炎症成分已得到广泛研究，但进行性神经退行性变仍是导致长期残疾的关键因素。因此，识别和验证与神经退行性变过程相关的生物标志物对于改善诊断、预后和治疗监测至关重要。本综述探讨了脑脊液（CSF）和血液中的生物标志物，包括神经丝、脂质标志物、犬尿氨酸和其他分子指标，这些指标为了解MS中的神经退行性变提供了线索。
