基于其体外抗黑素生成和抗纤维增殖特性的提取物在皮肤方面的潜在应用

Potential Cutaneous Applications of Extract Based on Its In Vitro Anti-Melanogenic and Anti-Fibroproliferative Properties.

作者信息

Salakshna Nuntida, Thanasarnaksorn Wilai, Kanjanasirirat Phongthon, Jearawuttanakul Kedchin, Chabang Napason, Rangkansenee Noppawan, Panich Uraiwan, Thanachaiphiwat Saowalak, Borwornpinyo Suparerk, Hongeng Suradej

机构信息

Samitivej Esthetics Institute, Samitivej Sukhumvit Hospital, Bangkok 10110, Thailand.

Science Division, Mahidol University International College, Nakhon Pathom 73170, Thailand.

出版信息

Int J Mol Sci. 2025 May 1;26(9):4319. doi: 10.3390/ijms26094319.

DOI:10.3390/ijms26094319

PMID:40362555

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12072697/

Abstract

The rhizomes of (fingerroot) and its bioactive compound, panduratin A, exhibit potent anti-inflammatory, antioxidant, and anti-proliferative properties. The aim of this study was to investigate the anti-melanogenic (including anti-tyrosinase) effects of extract and panduratin A in B16F10 melanoma cells induced by UVA radiation. The effects of the compounds on fibroblast proliferation and migration were also assessed by scratch wound healing assays in human primary fibroblasts. The results showed that extract and panduratin A significantly reduced tyrosinase activity and cellular melanogenesis induced by UVA radiation in a dose-dependent manner. The compounds also demonstrated inhibitory effects on fibroblast cell migration and proliferation. These findings suggest that extract may have potential therapeutic effects on skin hyperpigmentation and fibroproliferative skin disorders.

摘要

（指根姜）的根茎及其生物活性化合物盘多拉亭A具有强大的抗炎、抗氧化和抗增殖特性。本研究的目的是调查指根姜提取物和盘多拉亭A对UVA辐射诱导的B16F10黑色素瘤细胞的抗黑素生成（包括抗酪氨酸酶）作用。还通过人原代成纤维细胞的划痕伤口愈合试验评估了这些化合物对成纤维细胞增殖和迁移的影响。结果表明，指根姜提取物和盘多拉亭A以剂量依赖性方式显著降低了UVA辐射诱导的酪氨酸酶活性和细胞黑素生成。这些化合物还对成纤维细胞迁移和增殖表现出抑制作用。这些发现表明，指根姜提取物可能对皮肤色素沉着过度和纤维增生性皮肤病具有潜在的治疗作用。