Moolla Siddiq, Miller-Monthrope Yvette
Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Drugs Context. 2022 May 31;11. doi: 10.7573/dic.2021-11-2. eCollection 2022.
Hyperpigmentation disorders, such as post-inflammatory hyperpigmentation and melasma, are common conditions affecting all skin types. These conditions are largely benign and are influenced by numerous endogenous and exogenous factors impacting melanocyte activity and melanin production. Current treatment modalities for these conditions fall into broad categories, including photoprotection, topical and systemic therapies, chemical peels, and laser or light-based therapies. Biological differences in skin of colour require additional consideration when deciding on treatment and management. This narrative review provides an inclusive summary of these conditions and compares the current treatment options with a specific focus on skin of colour. Photoprotection and sunscreens protective against both UV and visible light are recommended for all individuals. Topical therapy is the recommended first-line treatment, with the gold standard being hydroquinone, which can be used alone or in combination with other agents. Chemical peels and laser or light-based therapies are also effective adjunctive methods of treatment; however, caution should be taken when used in patients with richly pigmented skin due to the increased risk of post-inflammatory hyperpigmentation.
色素沉着紊乱,如炎症后色素沉着和黄褐斑,是影响所有皮肤类型的常见病症。这些病症大多为良性,受多种影响黑素细胞活性和黑色素生成的内源性和外源性因素影响。目前针对这些病症的治疗方法大致可分为几大类,包括光防护、局部和全身治疗、化学剥脱以及激光或光基治疗。在决定治疗和管理方案时,肤色的生物学差异需要额外考虑。这篇叙述性综述全面总结了这些病症,并比较了当前的治疗选择,特别关注了有色人种皮肤。建议所有个体进行光防护,并使用能抵御紫外线和可见光的防晒霜。局部治疗是推荐的一线治疗方法,金标准是氢醌,它可单独使用或与其他药物联合使用。化学剥脱以及激光或光基治疗也是有效的辅助治疗方法;然而,由于炎症后色素沉着风险增加,在色素沉着丰富的皮肤患者中使用时应谨慎。