Yaglova Nataliya V, Obernikhin Sergey S, Timokhina Ekaterina P, Tsomartova Elina S, Yaglov Valentin V, Nazimova Svetlana V, Ivanova Marina Y, Chereshneva Elizaveta V, Lomanovskaya Tatiana A, Tsomartova Dibakhan A
Laboratory of Endocrine System Development, A.P. Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", 119991 Moscow, Russia.
Department of Human Anatomy and Histology, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia.
Int J Mol Sci. 2025 May 7;26(9):4448. doi: 10.3390/ijms26094448.
Water is a vital nutrient that is needed to maintain almost all biological processes in living organisms. The natural water contains two isotopes of hydrogen-protium and deuterium. Deuterium, the trace component of natural water, significantly changes its physical and chemical properties and biological action. In this review, the authors summarize data on the isotopic effects of deuterium and discuss the possible magnetic effects of isotopes and the molecular basis of the biological effects of deuterium-depleted water. The review also presents new data on the already known and potential use of deuterium-depleted water in medicine (oncology, neurology) and previously unknown new directions of its use (immunological and endocrine disorders, anemia). Based on the analysis of collected data, the authors presented mechanisms of action of deuterium-depleted water in the organism. The authors also identified the least-studied effects of deuterium-depleted water, particularly its influence on morphogenetic processes. The review discloses the perspectives on deuterium-depleted water as a tool for therapy and substantiates the risks of its uncontrolled intake.
水是一种至关重要的营养素，维持生物体中几乎所有的生物过程都需要它。天然水中含有氢的两种同位素——氢和氘。氘作为天然水的微量成分，会显著改变其物理和化学性质以及生物活性。在这篇综述中，作者总结了关于氘的同位素效应的数据，并讨论了同位素可能的磁效应以及低氘水生物效应的分子基础。该综述还展示了低氘水在医学（肿瘤学、神经病学）中已知和潜在用途的新数据，以及其此前未知的新应用方向（免疫和内分泌紊乱、贫血）。基于对收集数据的分析，作者阐述了低氘水在生物体内的作用机制。作者还确定了低氘水研究最少的效应，特别是其对形态发生过程的影响。该综述揭示了低氘水作为一种治疗手段的前景，并证实了无节制摄入低氘水的风险。
