Böttiger M, Christenson B, Taranger J, Bergman M
Vaccine. 1985 Jun;3(2):113-6. doi: 10.1016/0264-410x(85)90059-3.
In 1982-83, a unique, two-dose programme of immunization with a combined vaccine against measles, mumps and rubella was initiated in Sweden. The first dose was administered at 18 months and the second at 12 years of age. A vaccination study was carried out on 247 12 year old schoolchildren from four schools situated in two urban and two rural areas. In urban areas, 30% of children were found to be susceptible to rubella and 18% to mumps, compared with 55% susceptible to rubella and 31% to mumps in rural areas. The reverse was found for measles, to which 20% of children lacked immunity in urban areas but only 6% in rural areas. Seroconversion was seen in 82% against measles, in 80% against mumps and in 100% against rubella. Follow-up studies of the timing and the virus dosage are also to be carried out.
1982 - 1983年，瑞典启动了一项独特的、针对麻疹、腮腺炎和风疹联合疫苗的两剂免疫计划。第一剂在18个月时接种，第二剂在12岁时接种。对来自两个城市和两个农村地区四所学校的247名12岁学童进行了一项疫苗接种研究。在城市地区，发现30%的儿童对风疹易感，18%对腮腺炎易感，而在农村地区，55%的儿童对风疹易感，31%对腮腺炎易感。麻疹情况则相反，城市地区20%的儿童缺乏免疫力，而农村地区仅为6%。麻疹的血清转化率为82%，腮腺炎为80%，风疹为100%。还将对接种时间和病毒剂量进行后续研究。
