Therapeutic Potential of : Phytochemical Identification and Investigation of Antimicrobial, Anticancer, Pro-Wound-Healing, and Anti-Inflammatory Properties.

is a common park tree, with previous reports of some medicinal properties. In this work, we identified and explored phytochemicals from for potential antimicrobial, pro-wound-healing, anti-inflammatory, and effect on cancer cell lines' proliferation, both experimentally and bioinformatically. Gas chromatography/mass spectrometry (GC/MS) analysis was performed to identify the volatile compounds. The nonvolatile active components of the extract were identified by HPLC and LC-ESI-MS. We found that some drug-resistant microorganisms (, , , , and ) were inhibited by the extract, the 80% fraction, and all the identified flavonoids except quercetin 3--rutinoside. Furthermore, the extract and above-mentioned compound also inhibited the growth of biofilm-producing bacterium. The extract and 80% fraction were very potent ( < 0.001) at inducing death of MCF7 and U87 cancer cell cultures and were more effective in that than the chemotherapeutic agent doxorubicin which served as a positive control. Additionally, the extract of , the 80% fraction, and selected phytochemicals had pronounced pro-wound-healing properties. Finally, the extracts, the 80% fraction, caffeic acid, kaempferol 3--rutinoside, and kaempferol 3--robinobioside significantly inhibited the secretion of pro-inflammatory cytokines, IL-6 and IL-8 ( < 0.001). In conclusion, this comprehensive research revealed convincing and promising indications of significant therapeutic potential of a extract and its active phytochemicals.