老年性白内障与抗坏血酸负荷

Senile cataract and ascorbic acid loading.

作者信息

Ringvold A, Johnsen H, Blika S

出版信息

Acta Ophthalmol (Copenh). 1985 Jun;63(3):277-80. doi: 10.1111/j.1755-3768.1985.tb06805.x.

DOI:10.1111/j.1755-3768.1985.tb06805.x

Abstract

Serum, aqueous humour, and lens ascorbic acid levels were determined by high-performance liquid chromatography in cataract-, closed-angle glaucoma-, and aphakic patients. The total number of 108 patients were subdivided into different groups. In several groups the pre-operative serum and aqueous amounts were tested, whereafter patients in some groups were loaded with ascorbic acid orally. Finally, a second test was performed on samples taken during operation. It turned out that the ascorbic acid concentration mechanism in cataractous eyes needed more than 12 h for maximum reaction on the loading stimulus. The slow reaction is surprising compared to other species, and it may reflect an affection of the secretory process itself in this disease.

摘要

采用高效液相色谱法测定了白内障、闭角型青光眼和无晶状体患者的血清、房水和晶状体中的抗坏血酸水平。108名患者被分为不同的组。在几组患者中检测了术前血清和房水的量，之后部分组的患者口服抗坏血酸。最后，对手术期间采集的样本进行了第二次检测。结果表明，白内障眼中抗坏血酸的浓度机制在负荷刺激下需要超过12小时才能达到最大反应。与其他物种相比，这种缓慢的反应令人惊讶，它可能反映了这种疾病中分泌过程本身受到的影响。