Olsen T, Ehlers N, Nielsen C B, Beck-Nielsen H
Acta Ophthalmol (Copenh). 1985 Jun;63(3):315-9. doi: 10.1111/j.1755-3768.1985.tb06812.x.
Twenty-four insulin dependent juvenile diabetics, with no or minimal background retinopathy, were randomly allocated to conventional insulin therapy (CIT) or continuous subcutaneous insulin infusion (CSII) administrated by means of a portable pump. The metabolic control was significantly improved in the CSII group as compared to the CIT group. After one year, a progression of diabetic retinopathy (criterion: development of more than 2 microaneurysms) was observed in 3 of 12 patients in the CSII group and in 4 of 12 patients in the CIT group (P greater than 0.05). A tendency to more severe progression was observed in the CIT group. None developed soft exudates or retinal proliferations. Although no significant beneficial effect of pump treatment could be demonstrated, it seems safe to conclude that pump treatment does not accelerate progression of diabetic retinopathy in patients with no or minimal background retinopathy.
24名胰岛素依赖型青少年糖尿病患者，无背景性视网膜病变或仅有轻微背景性视网膜病变，被随机分配接受传统胰岛素治疗（CIT）或通过便携式泵进行持续皮下胰岛素输注（CSII）。与CIT组相比，CSII组的代谢控制得到显著改善。一年后，CSII组12名患者中有3名出现糖尿病视网膜病变进展（标准：出现超过2个微动脉瘤），CIT组12名患者中有4名出现进展（P大于0.05）。CIT组有更严重进展的趋势。无人出现软性渗出物或视网膜增殖。虽然未证明泵治疗有显著的有益效果，但可以有把握地得出结论：对于无背景性视网膜病变或仅有轻微背景性视网膜病变的患者，泵治疗不会加速糖尿病视网膜病变的进展。
