Movahed Mohammad Reza, Javanmardi Elimira, Hashemzadeh Mehrtash
University of Arizona Sarver Heart Center Tucson AZ USA.
College of Medicine University of Arizona Phoenix AZ USA.
J Am Heart Assoc. 2025 May 20;14(10):e037219. doi: 10.1161/JAHA.124.037219. Epub 2025 May 14.
Takotsubo cardiomyopathy continues to be a major cause of mortality and morbidity. The goal of this study was to evaluate the outcome data of patients with Takotsubo cardiomyopathy using a large inpatient database.
We used the Nationwide Inpatient Sample database for our study. We evaluated trends, mortality, and complications of patients admitted with Takotsubo cardiomyopathy from available years 2016 to 2020 in adults >18. A total of 199 890 patients with Takotsubo were found in our database with 83% being female and higher prevalence with age, White race, and highest income. Mortality was high at 6.5% with no significant improvement over the years studied. Furthermore, major complications were substantial. Cardiogenic shock occurred in 6.6%, atrial fibrillation in 20.7%, cardiac arrest in 3.4%, congestive heart failure in 35.9%, and stroke in 5.3%. Mortality was more than double in men in comparison to women (11.2% versus 5.5%).
Takotsubo cardiomyopathy is associated with high mortality and complications with no improvement in outcome over the 5-year study with higher mortality in men. Further improvement in care is needed to improve outcomes.
应激性心肌病仍然是导致死亡和发病的主要原因。本研究的目的是使用一个大型住院患者数据库来评估应激性心肌病患者的预后数据。
我们在研究中使用了全国住院患者样本数据库。我们评估了2016年至2020年期间18岁以上成年人中因应激性心肌病入院患者的趋势、死亡率和并发症情况。在我们的数据库中总共发现了199890例应激性心肌病患者，其中83%为女性，且随着年龄、白人种族和高收入水平患病率更高。死亡率为6.5%，在所研究的年份中没有显著改善。此外，主要并发症很严重。心源性休克发生率为6.6%，心房颤动为20.7%，心脏骤停为3.4%，充血性心力衰竭为35.9%，中风为5.3%。男性的死亡率是女性的两倍多（11.2%对5.5%）。
应激性心肌病与高死亡率和并发症相关，在为期5年的研究中预后没有改善，男性死亡率更高。需要进一步改善治疗以提高预后。
