Iida H, Izumino K, Matsumoto M, Takata M, Mizumura Y, Sugimoto T
Acta Pathol Jpn. 1985 May;35(3):561-7. doi: 10.1111/j.1440-1827.1985.tb00598.x.
Wistar rats rendered cirrhotic with carbon tetrachloride excreted significant proteinuria and hematuria. Serum levels of IgA and IgG were significantly elevated in cirrhotic animals. They showed mild mesangial proliferation and immunofluorescent studies revealed deposits of IgA and IgG predominantly in mesangial areas and along capillary walls. These findings were very similar to those seen in patients with hepatic cirrhosis or IgA nephropathy. The deposits of IgA were also found in hepatic tissue from cirrhotic animals. The intensity and distribution of glomerular IgA deposits were not diminished after treatment with acid buffer. These results suggest that glomerular IgA are IgA polymers and decreased hepatic clearance of hepatic IgA polymers may be responsible for the glomerular deposition of IgA.
用四氯化碳诱导形成肝硬化的Wistar大鼠出现了明显的蛋白尿和血尿。肝硬化动物的血清IgA和IgG水平显著升高。它们表现出轻度的系膜增生，免疫荧光研究显示IgA和IgG沉积物主要位于系膜区和沿毛细血管壁。这些发现与肝硬化或IgA肾病患者的情况非常相似。在肝硬化动物的肝组织中也发现了IgA沉积物。用酸性缓冲液处理后，肾小球IgA沉积物的强度和分布并未减弱。这些结果表明，肾小球IgA是IgA聚合物，肝脏对肝脏IgA聚合物清除率的降低可能是IgA在肾小球沉积的原因。
