Sharma Pooja, Singh Prabhjot, Wangoo Nishima
Department of Applied Sciences, University Institute of Engineering and Technology (U.I.E.T), Panjab University, Sector 25, Chandigarh, 160025, India.
Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224, Warsaw, Poland.
Chembiochem. 2025 May 14:e2500228. doi: 10.1002/cbic.202500228.
Self-assembly is defined as a spontaneous ordering of molecules into distinct supramolecular structures similar to the naturally occurring biomolecules such as DNA, lipids, and proteins. Interestingly, this strategy has gained huge importance in recent decades, leading to substantial advancements in the biomedical field, including drug delivery, biosensing, tissue engineering, etc. The unique role of "FF" moiety in promoting self-aggregation in larger proteins is well established owing to its frequent occurrence in amyloids. This finding comes as a breakthrough in peptide nanotechnology research leading to the exploration of various peptide-based supramolecular structures demonstrating exceptional functional roles with futuristic applications. In this regard, since amino acids are the building blocks of peptides, the detailed investigation and discussion regarding their self-assembly behavior are expected to provide important insights into designing advanced functional materials from amino acids and peptides. This review provides a systematic overview of various latest findings on amino acid-based self-assembly and its pathological as well as functional role. The review also highlights the importance of emerging applications from self-assembled amino acid-based nanomaterials in the field of material science and biomedicine.
自组装被定义为分子自发排列成独特的超分子结构，类似于天然存在的生物分子，如DNA、脂质和蛋白质。有趣的是，这种策略在近几十年来变得极为重要，推动了生物医学领域的重大进展，包括药物递送、生物传感、组织工程等。由于“FF”部分在淀粉样蛋白中频繁出现，其在促进较大蛋白质自聚集方面的独特作用已得到充分证实。这一发现是肽纳米技术研究的一项突破，促使人们探索各种基于肽的超分子结构，这些结构展现出非凡的功能作用并具有未来应用前景。在这方面，由于氨基酸是肽的组成部分，对其自组装行为的详细研究和讨论有望为从氨基酸和肽设计先进功能材料提供重要见解。本综述系统概述了基于氨基酸的自组装的各种最新发现及其病理和功能作用。该综述还强调了基于氨基酸的自组装纳米材料在材料科学和生物医学领域新兴应用的重要性。
