Moradi Maryam, Niazi Azin, Mohammadi Payandar Fereshteh, Jamali Jamshid, Arefadib Noushin
Global and Woman's Health, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.
PhD in Reproductive Health, Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Taiwan J Obstet Gynecol. 2025 May;64(3):512-518. doi: 10.1016/j.tjog.2024.10.020.
Many women experience high stress, anxiety or depression during pregnancy. The aim of this study was to determine the effect of aromatherapy with Citrus Aurantium essential oil on depression, stress and anxiety in pregnant women.
This randomized clinical trial included 68 pregnant women who were randomly assigned to either the intervention group where they received five drops of Citrus Aurantium essential oil or the control group where they received odorless sweet almond oil, both twice a day for one month in the form of facemasks which they inhaled through normal breathing for 20 min. The Depression, Anxiety, and Stress Scale-21 Items (DASS-21) were administered pre-and post-intervention. Data analysis was performed within SPSS software (version 24). P-value<0.05 was considered statistically significant.
The mean gestational age was 29.30 ± 2.14 weeks in the control group and 28.43 ± 1.95 weeks in the intervention group (p = 0.089). In bi-variable analysis, the intervention significantly improved all depression, anxiety and stress scores. Depression scores significantly decreased in the intervention group compared to the placebo group (-4.80 ± 6.22 vs. 1.03 ± 5.90) (p < 0.001). Similarly, anxiety scores were reduced after the intervention (-3.37 ± 3.52 vs. 0.79 ± 4.39) (p < 0.001). Although stress scores improved more in the intervention group compared to placebo group (-3.77 ± 4.94 vs. 1.39 ± 4.99), the difference was not statistically significant (p = 0.166). However, a more sophisticated analysis revealed that the intervention had a significant effect on depression (p = 0.001) and anxiety (p < 0.001) but not on stress (p = 0.166).
Aromatherapy with Citrus Aurantium essential oil is effective and safe in reducing depression and anxiety in pregnant women. However, further research is needed to clarify its impact on stress reduction.
IRCT20200512047414N1.
许多女性在孕期会经历高度紧张、焦虑或抑郁。本研究旨在确定使用酸橙精油进行芳香疗法对孕妇抑郁、压力和焦虑的影响。
这项随机临床试验纳入了68名孕妇，她们被随机分配到干预组（接受5滴酸橙精油）或对照组（接受无味甜杏仁油），两组均每天两次，持续一个月，以口罩形式通过正常呼吸吸入20分钟。在干预前后使用21项抑郁、焦虑和压力量表（DASS-21）进行评估。数据分析在SPSS软件（版本24）中进行。P值<0.05被认为具有统计学意义。
对照组的平均孕周为29.30±2.14周，干预组为28.43±1.95周（p = 0.089）。在双变量分析中，干预显著改善了所有抑郁、焦虑和压力得分。与安慰剂组相比，干预组的抑郁得分显著降低（-4.80±6.22对1.03±5.90）（p < 0.001）。同样，干预后焦虑得分也降低了（-3.37±3.52对0.79±4.39）（p < 0.001）。虽然与安慰剂组相比，干预组的压力得分改善更多（-3.77±4.94对1.39±4.99），但差异无统计学意义（p = 0.166）。然而，更深入的分析显示，干预对抑郁（p = 0.001）和焦虑（p < 0.001）有显著影响，但对压力无显著影响（p = 0.166）。
使用酸橙精油进行芳香疗法在减轻孕妇抑郁和焦虑方面有效且安全。然而，需要进一步研究以阐明其对减轻压力的影响。
IRCT20200512047414N1。
