Lanza F L, Nelson R S, Royer G L
Am J Gastroenterol. 1979 Nov;72(5):528-34.
Patients who have demonstrated a gastric mucosal sensitivity to aspirin often react to other nonsteroidal, anti-inflammatory drugs to a similar or lesser degree. In a single-blind crossover study, five healthy volunteers who had previously developed erosive gastritis secondary to one week of aspirin therapy were randomly assigned to seven-day courses of treatment with ibuprofen, tolmetin and placebo. Treatment schedules were separated by washout periods to eliminate residual drug effects. Ibuprofen produced less gastric mucosal injury than tolmetin and, over all, appeared to be better tolerated. It was also noted that clinical symptoms often do not reflect the severity of gastroscopic findings, which may explain silent hemorrhaging in patients treated with agents of this type.
已证明胃黏膜对阿司匹林敏感的患者，通常对其他非甾体抗炎药也会有相似程度或较轻程度的反应。在一项单盲交叉研究中，五名曾因一周阿司匹林治疗继发糜烂性胃炎的健康志愿者，被随机分配接受布洛芬、托美汀和安慰剂的七日疗程治疗。治疗方案之间有洗脱期以消除残留药物效应。布洛芬造成的胃黏膜损伤比托美汀少，总体而言似乎耐受性更好。还注意到临床症状往往不能反映胃镜检查结果的严重程度，这可能解释了使用这类药物治疗的患者出现无症状出血的情况。
